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A remarkable spectrum of novel immunoreceptors sharing related immunoglobulin-like domains and signaling potential has been identified in recent years. These receptors have attracted widespread interest because they resemble the TCR, BCR, and FcR complexes in their ability to serve as activating or inhibitory receptors on the cells that bear them. Moreover, they are well positioned to affect both innate and adaptive immunity. The full range of ligands for these new receptor families is still not known, and understanding of their physiological roles is far from complete. This volume is the first attempt to summarize and highlight all known aspects of immunoglobulin-like receptors, providing a topical overview of the roles and characteristic features of the immunoglobulin-like receptors and related molecules in the immune system. Researchers in immunology, molecular biology, cell biology, clinical medicine, and pharmacology will find this book invaluable.
The assassin's bullet misses, the Archduke's carriage moves forward, and a catastrophic war is avoided. So too with the history of life. Re-run the tape of life, as Stephen J. Gould claimed, and the outcome must be entirely different: an alien world, without humans and maybe not even intelligence. The history of life is littered with accidents: any twist or turn may lead to a completely different world. Now this view is being challenged. Simon Conway Morris explores the evidence demonstrating life's almost eerie ability to navigate to a single solution, repeatedly. Eyes, brains, tools, even culture: all are very much on the cards. So if these are all evolutionary inevitabilities, where are our counterparts across the galaxy? The tape of life can only run on a suitable planet, and it seems that such Earth-like planets may be much rarer than hoped. Inevitable humans, yes, but in a lonely Universe.
Drug resistance is a growing problem in today's society. Successful drugs are constantly being developed but there is always the risk that a small percent of the drug's target will be immune. These survivors can then lead to a new population, resistant to the action of this drug. New drugs are continuously under development to combat this problem, but these can, in turn, lead to new resistant populations. This problem is universal whether the target is to destroy a deadly virus, or an insect which is ravaging crop production. Development of new drugs is difficult and time consuming so it is of crucial importance that we understand the processes behind drug resistance. "Molecular Genetics of Drug Resistance" forms a vital and timely review of the genetic processes behind drug resistance. Starting with an overview of the area, each chapter focuses on a particular target with important sections on drug resistance in malaria and in cancer. Each chapter has been written by an acknowledged expert in the field and the careful work of the editors has ensured a consistent approach and presentation.
The Encyclopedia of Military Science provides a comprehensive, ready-reference on the organization, traditions, training, purpose, and functions of today’s military. Entries in this four-volume work include coverage of the duties, responsibilities, and authority of military personnel and an understanding of strategies and tactics of the modern military and how they interface with political, social, legal, economic, and technological factors. A large component is devoted to issues of leadership, group dynamics, motivation, problem-solving, and decision making in the military context. Finally, this work also covers recent American military history since the end of the Cold War with a special emphasis on peacekeeping and peacemaking operations, the First Persian Gulf War, the events surrounding 9/11, and the wars in Afghanistan and Iraq and how the military has been changing in relation to these events. Click here to read an article on The Daily Beast by Encyclopedia editor G. Kurt Piehler, "Why Don't We Build Statues For Our War Heroes Anymore?"
The world’s most revered and eloquent interpreter of evolutionary ideas offers here a work of explanatory force unprecedented in our time—a landmark publication, both for its historical sweep and for its scientific vision. With characteristic attention to detail, Stephen Jay Gould first describes the content and discusses the history and origins of the three core commitments of classical Darwinism: that natural selection works on organisms, not genes or species; that it is almost exclusively the mechanism of adaptive evolutionary change; and that these changes are incremental, not drastic. Next, he examines the three critiques that currently challenge this classic Darwinian edifice: that...
The Disunity of American Culture describes culture now, when different forces are influencing it than in the past, altering it to near incomprehensibility. Identity issues have an effect on culture and politics; more influential is the question of what support the state is obligated to provide the individual. John C. Caiazza seeks to explain how this situation came to be.He begins with an explanation of the origins of Protestantism in America. Caiazza describes how the American religion has declined and the recent responses the decline has provoked. Caiazza follows with an analysis of science as it presently exists in American culture. The work of three scientists prominent in their respecti...