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Diagnostic and Therapeutic Antibodies
Soon after the first description of monoclonal antibodies in 1976, there was enormous interest in the clinical application of antibodies, especially in the context of cancer. Antibodies appeared to offer the “magic bullet” that would allow the specific destruction of neoplastic cells. H- ever, many years’ effort resulted in very few cases of successful immu- therapy with antibodies. As a result there was a major backlash against antibody therapy, and the field lost a considerable amount of popularity. Fashion, in science as well as in other things, tends to be cyclical. Antibody-based therapy is once again attracting scientists and clinicians. There are several reasons for the renewed ...
The Lock and Key of Medicine
This book is the first to tell the extraordinary yet unheralded history of monoclonal antibodies, or Mabs. Though unfamiliar to most nonscientists, these microscopic protein molecules are everywhere, quietly shaping our lives and healthcare. They have radically changed understandings of the pathways of disease, enabling faster, cheaper, and more accurate clinical diagnostic testing. And they lie at the heart of the development of genetically engineered drugs such as interferon and blockbuster personalized therapies such as Herceptin. Lara V. Marks recounts the risks and opposition that a daring handful of individuals faced while discovering and developing Mabs, and she addresses the related scientific, medical, technological, business, and social challenges that arose. She offers a saga of entrepreneurs who ultimately changed the healthcare landscape and brought untold relief to millions of patients. Even so, controversies over Mabs remain, which the author explores through the current debates on their cost-effectiveness.
It's Alright Leaving Me...!
'It's alright leaving me ...' was a claim often heard down a crackly control line from a television technician like Geoff Hale in a far-flung foreign TV station, when a request had come from BBC London to explain some inferior pictures arriving back at the Television Centre in White City. Between 1963 and 1998 Geoff worked as a Chief Picture Editor for BBC TV News, travelling all over the world and witnessing at first hand some of the major news stories of the time. Many books have been written of this period giving the TV Reporter's account of these happenings, but in this fascinating book Geoff gives a technician's eye view of some of the famous events which marked the end of the 20th century.
Monoclonal Antibodies
Monoclonal Antibodies: A Practical Approach covers the preparation, testing, derivation, and applications of monoclonal antibodies. New immunological techniques incorporating tried and tested methodologies are described, making the book of interest to established and inexperienced immunologists. Both the standard somatic hybridization technique and recombinant techniques, including the use of phage libraries, for the preparation of rodent and human monoclonal antibodies are described. Protocols for both the small and large scale production are detailed, as well as purification and labelling (with both radioisotopes and non-radioisotopes) methods. The applications of monoclonal antibodies in immunoblotting, enzyme linked immunoassays, immunofluorescence, and FACS analysis are all covered in detail. Finally protocols are given for the use of monoclonal antibodies in rheumatoid arthritis, tissue typing, detecting DNA modified during chemotherapy, and in the clinical analysis of transplantation samples for malignancy. This book will therefore be an invaluable laboratory companion to anyone using monoclonal antibodies in their research.
Cruising World
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Handbook of Mould, Tool and Die Repair Welding
This book covers an important and frequently overlooked area of welding - the repair of moulds, tools and dies. Because two rather different trades overlap in this process - welding and toolmaking, the materials and techniques involved have tended to be obscured. For many years, toolmakers and tool users have had to rely on the small number of specialist welders who do understand exactly what welding repair involves and have the skills to carry it out.Understanding the technical side of tool steels is frequently a problem for welders and understanding the practical side of welding can be a problem for machinists. This book has been written so that specialists from both sides can get to grips...
Publishing E-Books For Dummies
Publish, market, and sell your own e-book Although creating an e-book seems fairly straightforward, it is not. You need to select and create a variety of formats that will be read on a variety of e-reader devices--and market and sell your book in a variety of ways. Before you take the plunge, get this practical guide. With clear instruction and sensible advice, it will help you navigate the often confusing, time-consuming, and costly world of self-publishing an e-book. The book gives you solid marketing tips for selling your e-book, including using blogging and social media and how to build an online platform. It also discusses key technologies you'll encounter, including Smashwords, iBooks ...
Fracture Mechanics Testing Methods for Polymers, Adhesives and Composites
This book is an overview of ESIS Technical Committee 4's activities since the mid-1980s. A wide range of tests is described and the numerous authors is a reflection of the wide and enthusiastic support we have had. With the establishment of the Technical Committee 4, two major areas were identified as appropriate for the activity. Firstly there was an urgent need for standard, fracture mechanics based, test methods to be designed for polymers and composites. A good deal of academic work had been done, but the usefulness to industry was limited by the lack of agreed standards. Secondly there was a perceived need to explore the use of such data in the design of plastic parts. Some modest efforts were made in early meetings to explore this, but little progress was made. In contrast things moved along briskly in the standards work and this has dominated the activity for the last fourteen years. The design issue remains a future goal.
Nanoparticles in Cancer Therapy
This book presents the role of nanoparticles in cancer therapy, emphasizing their innovative applications across treatment, diagnosis and the development of therapeutic strategies. The first section of the book describes the applications of nanoparticles in cancer vaccines and gene therapy. It features discussions on polymeric nanoparticles as nanovaccine carriers, membrane-based nano-vaccines for immunotherapy and gene therapy techniques employing nanoparticles. The second section presents advanced nanomedicine approaches, specifying the role of chemodynamic nanoparticles in cancer theranostics, the application of low-dimensional nanomaterials and emerging strategies against drug resistance...
Clinical Bone Marrow and Blood Stem Cell Transplantation
Drs Richard Champlin, Jerome Ritz, Willem Fibbe, Per Ljungman, and Malcom K. Brenner join Kerry Atkinson as editors of this definitive reference on the clinical practice and underlying science of hematopoietic stem cell transplantation. This third edition text is significantly revised and updated with 124 chapters balancing scientific explanations with practical information on patient care for all aspects of autologous, syngeneic, and allogeneic transplantation. This edition includes 18 new chapters on significant topics such as plasticity of stem cells, embryonic stem cells, and nonmyeloablative conditioning regimens. Thoroughly referenced through 2003, the chapters are divided into 15 sections, including biological background and practical procedures, clinical results, transplant-related and organ-specific complications, laboratory aspects, and developing areas, with a final 'breaking news' chapter from this rapidly evolving field. Over 170 internationally-recognized experts contributed to this authoritative and practical text that is an essential resource for hematologists, oncologists, and transplant specialists.
