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Molecular Therapies of Cancer
Molecular Therapies of Cancer comprehensively covers the molecular mechanisms of anti-cancer drug actions in a comparably systematic fashion. While there is currently available a great deal of literature on anti-cancer drugs, books on the subject are often concoctions of invited review articles superficially connected to one another. There is a lack of comprehensive and systematic text on the topic of molecular therapies in cancer. A further deficit in the relevant literature is a progressive sub-specialization that typically limits textbooks on cancer drugs to cover either pharmacology or medicinal chemistry or signal transduction, rather than explaining molecular drug actions across all those areas; Molecular Therapies of Cancer fills this void. The book is divided into five sections: 1. Molecular Targeting of Cancer Cells; 2. Emerging and Alternative Treatment Modalities; 3. Molecular Targeting of Tumor-Host Interactions; 4. Anti-Cancer Drug Pharmacokinetics; and 5. Supportive Therapies.
New York in the revolution as colony and state
these records were discovered, arranged and classified in 1895, 1896, 1897 and 1898
How Complexity Shapes the World
This book explores how we may overcome categorizations and opposites in how we explain all existence. It places such ideas into the context of existing complexity paradigms. Research into complex systems has revolutionized virtually all areas of inquiry over the past half century. The algorithms of non-linear systems research have enabled us to unify descriptions of the world that were distinct under traditional, reductionist explorations. It is the beauty of complexity that it brings together various scientific fields that, in the past, were treated as separate entities under specialized study. They are now found to be governed by the same laws of non-linearity. However, this achievement comes at the price of abstraction and open-endedness. The book is motivated by the philosophical desire to eliminate categorizations and opposites in the sciences and arrive at a unified description of nature and society. To the reader, it offers innovative philosophical insights derived from complexity research.
The Book of Names, Especially Relating to the Early Palatines and the First Settlers in the Mohawk Valley
When originally published in 1933, this classic work listed for the first time the names of the early Palatines of New York State, the original settlers of the Mohawk Valley, known as the "Gateway to the West." The estimated 20,000 names are classified, combined, and otherwise arranged to enable the researcher to identify Palatine immigrants in relation to specific categories of records. Among the important lists of names are the following: (1) The Kocherthal records of baptisms, marriages, and deaths, 1708-1719; (2) Palatine heads of families, from Gov. Hunter's Ration Lists, 1710-1714; (3) Lists of Palatines in 1709 (the four London lists of emigrants from Germany, most of whom emigrated to America); (4) Palatines remaining and newly arrived in New York, from the colonial census of 1710; (5) Names of Palatine children apprenticed by Gov. Hunter, 1710-1714; and (6) Various lists of Palatines in the colonial militia of New York.
Cancer Metabolism: Molecular Targeting and Implications for Therapy
Development of an effective anticancer therapeutic necessitates the selection of cancer-related or cancer-specific pathways or molecules that are sensitive to intervention. Several such critical yet sensitive molecular targets have been recognized, and their specific antagonists or inhibitors validated as potential therapeutics in preclinical models. Yet, majority of anticancer principles or therapeutics show limited success in the clinical translation. Thus, the need for the development of an effective therapeutic strategy persists.
“Altered energy metabolism” in cancer is one of the earliest known biochemical phenotypes which dates back to the early 20th century. The German ...
Molecular Mechanisms of Cancer
This book describes molecular processes whose deregulation is important in the formation of tumors. The material is developed from basic cell signaling pathways to their roles in the clinical manifestation of specific cancers. Topics covered include molecular events intrinsic to tumor cells (leading to growth deregulation, extended lifespan, and the ability to invade surrounding tissue), protective mechanisms that prevent transformation (including DNA repair and epigenetic regulation), tumor-host interactions (with the endocrine system, the immune system, and blood vessel formation), and the underlying molecular defects of individual cancers.
Women in Cancer Immunity and Immunotherapy
At present, less than 30% of researchers worldwide are women. Long-standing biases and gender stereotypes are discouraging girls and women away from science-related fields, and STEM research in particular. Science and gender equality are, however, essential to ensure sustainable development as highlighted by UNESCO. In order to change traditional mindsets, gender equality must be promoted, stereotypes defeated, and girls and women should be encouraged to pursue STEM careers. Therefore, Frontiers in Immunology is proud to offer this platform to promote the work of women scientists, across all fields of Cancer Immunity and Immunotherapy.
Metabolism Meets Function: Untangling the Cross-Talk Between Signalling and Metabolism
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
