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Both an intellectual autobiography and a chronicle of the ideological and methodological upheaval in textual studies during the last two decades, this book presents provocative essays by one of the foremost textual scholars of our day. As founder and executive director of the interdisciplinary Society for Textual Scholarship, Professor Greetham has had the opportunity to observe and engage with the main players of the textual revolution during its most turbulent years and enlivens his account with revealing character sketches.
The purpose of this volume is to highlight wide-ranging applications of genomics in the area of applied mycology and biotechnology.The volume covers: a brief overview on fungal genomics; meiotic recombination in fungi; molecular genetics of circadian rhythms; genome sequencing; transposable elements; mitochondrial genomes; ribosome biogenesis; pathogenicity genes; genetic improvement of yeasts; microarrays: techniques and applications; fungal germplasm and data bases. Although it is difficult to develop a comprehensive volume on fungal genomics because of the range and complexity of the emerging knowledge, an attempt has been made to bring together pertinent information that will serve the needs of the reader, provide a quick reference to material that might otherwise be difficult to locate, and furnish a starting point for further study.
Mitochondria and chloroplasts are eukaryotic organelles that evolved from bacterial ancestors and harbor their own genomes. The gene products of these genomes work in concert with those of the nuclear genome to ensure proper organelle metabolism and biogenesis. This book explores the forces that have shaped the evolution of organelle genomes and the expression of the genes encoded by them. Some striking examples of trends in organelle evolution explored here are the reduction in genome size and gene coding content observed in most lineages, the complete loss of organelle DNA in certain lineages, and the unusual modes of gene expression that have emerged, such as the extensive and essential mRNA editing that occurs in plant mitochondria and chloroplasts. This book places particular emphasis on the current techniques used to study the evolution of organelle genomes and gene expression.
The complexity of cancer demands an integrated approach from both a cancer biology standpoint and a pharmaceutical basis to understand the different anticancer modalities. Current research has been focused on conventional and newer anticancer modalities, recent discoveries in cancer research, and also the advancements in cancer treatment. There is a current need for more research on the advances in cancer therapeutics that bridge the gap between basic research (pharmaceutical drug development processes, regulatory issues, and translational experimentation) and clinical application. Recent promising discoveries such as immunotherapies, promising therapies undergoing clinical trials, synthetic...
Diese Edition stellt eine einzigartige Quelle zum Verstandnis der Modernisierungsentwicklung des Heiligen Romischen Reiches im 15. Jahrhundert dar. Sie zeigt eindrucksvoll, dass sich gerade in dieser Zeit ein struktureller Verfassungswandel vollzog, der mit einer institutionellen Verdichtung und einem so seit langem nicht mehr registrierten Autoritatszuwachs des Kaisertums einherging. Entstanden sind die Texte, als das oberste kaiserliche Gericht an Reichsfursten verpachtet war, die allergrosstes Interesse daran hatten, die aus der Rechtsprechungstatigkeit erwachsenen Einnahmen zu erhohen. Sie waren deshalb bestrebt, alle rechtlich relevanten Vorgange schriftlich festzuhalten. Die im Wiener Haus-, Hof- und Staatsarchiv sowie im Tiroler Landesarchiv uberlieferten Geschaftsbucher und Fragmente, die durch das kurzlich edierte Taxregister des kaiserlichen Hofes erganzt werden mussen und im Zusammenhang mit dem Entwurf einer Kammergerichtsordnung von 1471 stehen, wurden hier durch ein Verzeichnis der Verfahren systematisiert und durch ein umfassendes Register erschlossen.