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This two-volume set LNCS 3760/3761 constitutes the refereed proceedings of the three confederated conferences CoopIS 2005, DOA 2005, and ODBASE 2005 held as OTM 2005 in Agia Napa, Cyprus in October/November 2005. The 89 revised full and 7 short papers presented together with 3 keynote speeches were carefully reviewed and selected from a total of 360 submissions. Corresponding with the three OTM 2005 main conferences CoopIS, DOA, and ODBASE, the papers are organized in topical sections on workflow, workflow and business processes, mining and filtering, petri nets and processs management, information access and integrity, heterogeneity, semantics, querying and content delivery, Web services, a...
Buddhism in the United States is often viewed in connection with practitioners in the Northeast and on the West Coast, but in fact, it has been spreading and evolving throughout the United States since the mid-nineteenth century. In Dixie Dharma, J
Selected, peer reviewed papers from the International Conference on Intelligent Structure and Vibration Control (ISVC 2012), March 16-18, 2012, Chongqing, China
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This comprehensive handbook covers all fundamentals of electrochemistry for contemporary applications. It provides a rich presentation of related topics of electrochemistry with a clear focus on energy technologies. It covers all aspects of electrochemistry starting with theoretical concepts and basic laws of thermodynamics, non-equilibrium thermodynamics and multiscale modeling. It further gathers the basic experimental methods such as potentiometry, reference electrodes, ion-sensitive electrodes, voltammetry and amperometry. The contents cover subjects related to mass transport, the electric double layer, ohmic losses and experimentation affecting electrochemical reactions. These aspects o...
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Nuclear Architecture and Dynamics provides a definitive resource for (bio)physicists and molecular and cellular biologists whose research involves an understanding of the organization of the genome and the mechanisms of its proper reading, maintenance, and replication by the cell. This book brings together the biochemical and physical characteristics of genome organization, providing a relevant framework in which to interpret the control of gene expression and cell differentiation. It includes work from a group of international experts, including biologists, physicists, mathematicians, and bioinformaticians who have come together for a comprehensive presentation of the current developments i...
Epigenetics and Systems Biology highlights the need for collaboration between experiments and theoretical modeling that is required for successful application of systems biology in epigenetics studies. This book breaks down the obstacles which exist between systems biology and epigenetics researchers due to information barriers and segmented research, giving real-life examples of successful combinations of systems biology and epigenetics experiments. Each section covers one type of modeling and one set of epigenetic questions on which said models have been successfully applied. In addition, the book highlights how modeling and systems biology relate to studies of RNA, DNA, and genome instability, mechanisms of DNA damage signaling and repair, and the effect of the environment on genome stability. - Presents original research in a wider perspective to reveal potential for synergies between the two fields of study - Provides the latest experiments in primary literature for the modeling audience - Includes chapters written by experts in systems biology and epigenetics who have vast experience studying clinical applications
Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin reader proteins. The first few drugs are already FDA approved and hav...