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Host defense to intracellular pathogens depends upon both innate and adaptive cell-mediated immune responses. Polymorphonuclear neutrophil leukocytes which belong to the innate immune system are the first cells that are recruited massively within hours of
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The parasitic disease leishmaniasis in its various clinical manifestations from self-resolving skin lesion to deadly systemic infection is a serious health problem in many developing countries and is considered to be a neglected tropical disease by the World Health Organization. To date, a vaccine is lacking and strategies to treat severe forms of leishmaniasis efficiently are missing. Basic research using animal models of experimental visceral or cutaneous leishmaniasis has allowed to dissect the immune response to parasitic pathogens and has contributed substantially to many important, paradigm-changing insights such as the role of cytokines in helper T-cell differentiation and the impact ...
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Leven en werk van Hugo Brandt Corstius – Opperlands geniale woordkunstenaar en Nederlands meest gevreesde polemist Gedurende een halve eeuw heeft Hugo Brandt Corstius als geen ander het publieke debat in Nederland gedomineerd. Onder de namen Piet Grijs, Battus, Stoker, Maaike Helder, Jan Eter en tientallen andere pseudoniemen haalde hij in alle media die ertoe deden de autoriteiten het bloed onder de nagels vandaan – met ijzersterke logica en met humor. Wegens zijn ‘kwetsende’ columns weigerde het kabinet hem de P.C. Hooft-prijs, die hij later alsnog kreeg. In haar grandioze, sprankelende en vlot geschreven biografie van Hugo Brandt Corstius onderzoekt Elsbeth Etty wat deze gevreesde polemist, getalenteerde humorist en geniale woordkunstenaar van Opperlandse taal- & letterkunde dreef. Ze belicht zijn door de Tweede Wereldoorlog bepaalde achtergrond en jeugd, zijn vaak visionaire kijk op zaken, zijn met mystificaties omgeven privéleven en zijn opzienbarende, veelal geheime liefdesaffaires. Naar eigen zeggen loog Brandt Corstius nooit, maar veel heeft hij verzwegen...
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.