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This book discusses the community of microbial species (the microbiota, microbiome), which inhabits the large bowel of humans. Written from the perspective of an academic who has been familiar with the topic for 40 years, it provides a long-term perspective of knowledge about this high profile and fast-moving topic. Building on general ecological principles, the book aims to help the reader to understand how the microbiota is formed, how it works, and what the consequences are to humans. Understanding the Gut Microbiota focuses on conceptual progress made from studies of the human bowel microbiota. Where appropriate, it draws on knowledge obtained from other animal species to provide concept...
This book is about the microbial species that inhabit the human body, and the consequences of the intimate relationships that we share with them. It is intended that the book will provide an introduction to the normal microflora for those studying disciplines within the health sciences, and for those in the food industry where interest in the microbiology of the digestive tract, especially with respect to lactic acid bacteria, is topical.
It has been estimated that there are more microbial cells inhabiting the human body than there are eukaryotic cells of which it is made up. This normal microflora usually co-exists relatively peacefully with the host and does not cause infection. The mechanisms by which this co-existence is achieved are still not properly understood and the interaction between the normal microflora and the host is far from simple. For a variety of reasons, however, this interaction can be disturbed and often results in the microflora becoming pathogens. The study of the diseases then caused is important both in terms of treatment and in terms of contributing to our understanding of the mechanisms by which th...
Ch.1 -- Molecular methods in microbial ecology; Ch.2 -- Taxonomy of lactobacilli and bifidobacteria; Ch.3 -- The microbiology of lactobacilli in the gastrointestinal tract; Ch.4 -- Exopolysaccharide production by intestinal lactobacilli; Ch.5 -- Beyond genome sequences: approaches to genome-wide analysis of gut bacteria; Ch.6 -- Molecular interactions of commensal enteric bacteria with the intestinal epithelium and the mucosal immune system: implications for chronic intestinal inflammation; Ch.7 -- Genetically modified probiotics; Ch.8 -- Bacterial therapeutics for the treatment and prevention of urogenital infections; Ch.9 -- Prebiotics and the infant microbiota; Ch.10 -- The tangled bank and gut microbial ecology.
In recent years the gastrointestinal microflora has featured strongly in scientific, veterinary and medical research. As a result it has become obvious that the gut microflora is an essential component of the healthy animal. Not only is it involved in digestion of food, it is essential for the optimal resistance to disease. The first part of this book records the research that has been done on the factors affecting colonization of the gut and the effect that the flora has on the host animal. The second part discusses the way in which this basic knowledge affects the choice of organism being used as a probiotic. The evidence for the involvement of the gut microflora in the health and well-bei...
"You take antibiotics to fight an infection. Unfortunately, the treatment also kills the community of bacteria in your gut microbiome; you now have digestion issues. You might start eating yogurt to reintroduce good bacteria. Or, if the bacterial community is more significantly disordered, you might need a "fecal microbiota transplant" - a doctor transfers stool from a healthy donor into your gut. The new bacteria community thrives, and you can again digest your food. If all the same types of bacteria are present in this new community, has your microbiome "regenerated"? What if the bacteria are completely different, but they perform the same function? How do the answers to these questions ch...
Historical Background lowe my interest in the lactic acid bacteria (LAB) to the late Dr Cyril Rainbow, who introduced me to their fascinating world when he offered me a place with him to work for a PhD on the carbohydrate meta bolism of some lactic rods isolated from English beer breweries by himself and others, notably Dr Dora Kulka. He was particularly interested in their preference for maltose over glucose as a source of carbohydrate for growth, expressed in most cases as a more rapid growth on the disaccharide, but one isolate would grow only on maltose. Eventually, we showed that maltose was being utilised by 'direct fermen tation' as the older texts called it, specifically by the phosp...
Probiotics: A Clinical Guide is one of the first books on the market to present current and evidence-based recommendations for primary care providers and gastroenterologists on the use of probiotics as a way to treat specific diseases and disorders. Why you will want Probiotics: A Clinical Guide: Unique focus on the clinical use of probiotics in a wide variety of diseases Comprehensive review of the science behind probiotics and probiotic products In-depth review of current literature for specific diseases or disorders Recommendations of the use of probiotics is supported by evidence-based clinical trials Each chapter includes a table that outlines the exact probiotic organisms and dosages t...
The shock following the recent outbreak of foot-and-mouth disease (FMD) in the UK dispelled the notion that this disease was permanently under control and could be forgotten. FMD proved to be an endemic disease in many countries and continues to pose a major threat to animal health worldwide. The development of more effective and socially acceptabl
Probiotics in Pediatric Medicine provides clinicians a tool to understand the current evidence for the role of probiotics in various pediatric disorders related to the gastrointestinal as well as the extra-intestinal tract. This book provides evidence-based up-to-date information from world experts in their fields to help clinicians make decisions regarding the use of probiotics. A list of resources, web sites, and references relevant to probiotics can be found in the appendix. Currently, the market for probiotics continues to rely heavily on health claims made by manufacturers and retailers. Clinicians have the sole responsibility to understand the various strains and preparations commercially available and to advise patients accordingly. Probiotics in Pediatric Medicine is an indispensable tool and a critical resource for health professionals that will aid in enhancing their ability to make the appropriate decisions regarding the use of probiotics.