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The biennial TNF-family conferences have been held over the past 20 years, from the time that TNF was cloned. These meetings have followed the enormous progress in this field. Much is now known about the members of the TNF ligand and receptor families, their signaling proteins, mechanisms of action and cellular functions. This volume is the proceedings of the 12th TNF International Conference, held in April 2009. This conference focuses on the physiological, pathophysiological, and medical significance of these important regulators. Sessions at the meeting specifically address their involvement in immunity, development, apoptosis, autoimmunity, cancer, and infection, the normal function and pathology of the neuronal system, as well as major unresolved questions about their mechanisms of action.
In contrast to the substantial literature that focuses upon innate immune signaling in the gut, there is remarkably less known about the response of the airway to bacterial pathogens. The purpose of this book will be to review the current status of theunderstanding of the pathogenesis of acute bacterial pneumonia, slanted toward the mucosal immunology of these infections. It will describe, in general, the signaling cascades that control the proinflammatory response to bacterial infection in the lung. How innate immune signaling is orchestrated in response to specific common airway pathogens is addressed, targeting Staphylococus aureus (including MRSA), Streptococcus pneumoniae and Klebsiella pneumoniae. By describing the general immunological responses to conserved bacterial components and then detailing how specific organisms cause infection, this book provides a targeted but comprehensive review of this important topic.
This collection of historical, philosophical, sociopolitical, and literary essays examines the linkages between the Iberian Peninsula and Latin America.
Offering a fresh, revisionist analysis of Spanish fiction from 1900 to 1940, this study examines the work of both men and women writers and how they practiced differing forms of modernism. As Roberta Johnson notes, Spanish male novelists emphasized technical and verbal innovation in representing the contents of an individual consciousness and thus were more modernist in the usual understanding of the term. Female writers, on the other hand, were less aesthetically innovative but engaged in a social modernism that focused on domestic issues, gender roles, and relations between the sexes. Compared to the more conventional--even reactionary--ways their male counterparts treated such matters, Sp...
List for March 7, 1844, is the list for September 10, 1842, amended in manuscript.
This anthology examines Love's Labours Lost from a variety of perspectives and through a wide range of materials. Selections discuss the play in terms of historical context, dating, and sources; character analysis; comic elements and verbal conceits; evidence of authorship; performance analysis; and feminist interpretations. Alongside theater reviews, production photographs, and critical commentary, the volume also includes essays written by practicing theater artists who have worked on the play. An index by name, literary work, and concept rounds out this valuable resource.
Vol. 1 includes "Organization number," published Nov. 1917.