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The biennial TNF-family conferences have been held over the past 20 years, from the time that TNF was cloned. These meetings have followed the enormous progress in this field. Much is now known about the members of the TNF ligand and receptor families, their signaling proteins, mechanisms of action and cellular functions. This volume is the proceedings of the 12th TNF International Conference, held in April 2009. This conference focuses on the physiological, pathophysiological, and medical significance of these important regulators. Sessions at the meeting specifically address their involvement in immunity, development, apoptosis, autoimmunity, cancer, and infection, the normal function and pathology of the neuronal system, as well as major unresolved questions about their mechanisms of action.
In contrast to the substantial literature that focuses upon innate immune signaling in the gut, there is remarkably less known about the response of the airway to bacterial pathogens. The purpose of this book will be to review the current status of theunderstanding of the pathogenesis of acute bacterial pneumonia, slanted toward the mucosal immunology of these infections. It will describe, in general, the signaling cascades that control the proinflammatory response to bacterial infection in the lung. How innate immune signaling is orchestrated in response to specific common airway pathogens is addressed, targeting Staphylococus aureus (including MRSA), Streptococcus pneumoniae and Klebsiella pneumoniae. By describing the general immunological responses to conserved bacterial components and then detailing how specific organisms cause infection, this book provides a targeted but comprehensive review of this important topic.
The essays examine the linkages between the Iberian Peninsula and Latin America in the area of intellectual production over the centuries. No other book provides such a broad coverage of the most significant intellectual influences between the Iberian Peninsula and Latin America. At the same time, it treats each case study with unparalleled interdisciplinary depth. Original essays by some of the most accomplished scholars from Europe, Latin America, and the United States address not only the question of the meaning of the Quincentennial of the Encounter, but also provide the first reflection on what lies ahead in terms of a research agenda and broader questions concerning the relationship between Europe and Latin America. The last ten years have been marked by an increasing interest in colonial and postcolonial studies. However, there has been a lack of anthologies in English chronicling the complex relationship between Spain, Latin America, and its colonial legacy. Bridging the Atlantic helps to fill this gap and stimulates new "dialectical encounters," as well as more comparative research on postcolonial questions.
List for March 7, 1844, is the list for September 10, 1842, amended in manuscript.