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Never has so much progress been reported in immunology as at this congress. The full impact of new technologies, developed since the late 1970s, has come to fruition: gene isolation, mutation, transfection and expression, protein structure and peptide synthesis, cell cloning, hybridization and monoclonal antibodies, CD serology, SCID and transgenic mice, modern immunomudulation and vaccines. An overwhelming mass of data has accumulated over the last years. The reports are up-to-date and outstanding, to a degree no journal will ever achieve, and the results are presented in a concise and lucid way. This report will serve as a guideline for generations of immunologists to come. Hundreds of new alleys have been opened, an abundance of research tools and goals are pointed to. This volume is a treasure trove of explorations ahead of our time - it is exciting reading. This progress report presents outstanding contributions, worth many prizes - a feature which is unusual for proceedings volumes. Immunology is exhibited at its best: an exciting research area and a rewarding subject to study for the benefit of mankind - today more than ever!
Georges Köhler was one of the most prominent German scientists of recent history. In 1984, at an age of 38, he received the Nobel Prize in Physiology or Medicine, together with N.K. Jerne and C. Milstein, for inventing the technique for generating monoclonal antibodies. This method and its subsequent applications had an enormous impact on basic research, medicine and the biotech industry. In the same year, Köhler became one of the directors of the Max-Planck-Institute of Immunobiology in Freiburg; his unfortunate premature death in 1995 set an end to his extraordinary career. Prof. Klaus Eichmann, who had invited Köhler to become his codirector, is one of the people who were closest to him. This scientific biography commemorates the 10th anniversary of Köhler's untimely death. Köhler's scientific achievements are explained in a way to make them understandable for the general public and discussed in the historical context of immunological research.
First multi-year cumulation covers six years: 1965-70.
Das 50-jährige Jubiläum der Deutschen Gesellschaft für Immunologie bietet die einmalige Chance, sowohl die wissenschaftlichen Triumphe als auch die Entwicklung des Fachs Immunologie in der deutschen Forschungslandschaft von der Vergangenheit bis in die Gegenwart näher zu beleuchten. In diesem Band wird die Entwicklung der immunologischen Fachgesellschaften in der ehemaligen BRD und DDR nach 1945 und deren Zusammenführung nach der Wiedervereinigung in den Blick genommen. Ausführlich dargestellt wird aber auch der Zeitraum von der Entdeckung und der ersten klinischen Anwendung der Antikörper durch Emil von Behring, Shibasaburo Kitasato und Paul Ehrlich über den unglaublichen Niedergang der Immunologie mit dem Exodus hervorragender klinischer Immunologen nach 1930 bis hin zur Entwicklung der Hybridomtechnik durch Georges Koehler und César Milstein im Jahre 1975. Mit zahlreichen Abbildungen.
Human immunosenescence contributes to morbidity and mortality in later life. Understanding the reasons for age-associated alterations to protective immunity in the elderly would ultimately improve and extend healthspan. The majority of the papers collected in this remarkable and timely volume address the mechanisms responsible for immune ageing in humans. They also consider what might be accomplished to redress the erosion of immune competence with age.
Unter Mitarbeit von Gerdes, Nikolaus Geleitwort von Riesenhuber, H.