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Animals are widely used in neuroscience research to explore biological mechanisms of nervous system function, to identify the genetic basis of disease states, and to provide models of human disorders and diseases for the development of new treatments. To ensure the humane care and use of animals, numerous laws, policies, and regulations are in place governing the use of animals in research, and certain animal regulations have implications specific to neuroscience research. To consider animal research regulations from a global perspective, the IOM Forum on Neuroscience and Nervous System Disorders, in collaboration with the National Research Council and the Institute for Laboratory Animal Research, held a workshop in Buckinghamshire, UK, July 26-27, 2011. The workshop brought together neuroscientists, legal scholars, administrators, and other key stakeholders to discuss current and emerging trends in animal regulations as they apply to the neurosciences. This document summarizes the workshop.
Living Memory investigates the complex question of language and its place at the heart of Bergamasco culture in northern Italy. • Integrates extensive participant observation with sociolinguistic data collection • Reveals the political and social dynamics of a national language (Italian) and a local dialect (Bergamasco) struggling for survival • Introduces the original concept of the “social aesthetics of language”: the interweaving of culturally-shaped and emotionally felt dimensions of language-choice • Written to be accessible to students and specialists alike • Part of the Blackwell Studies in Discourse and Culture Series
Techniques for microfabricating intricate microfluidic structures that mimic the microenvironment of tissues and organs, combined with the development of biomaterials with carefully engineered surface properties, have enabled new paradigms in and cell culture-based models for human diseases. The dimensions of surface features and fluidic channels made accessible by these techniques are well-suited to the size scale of biological cells. Microfluidic Cell Culture Systems applies design and experimental techniques used in in microfluidics, and cell culture technologies to organ-on-chip systems. This book is intended to serve as a professional reference, providing a practical guide to design and...
Organ-on-a-Chip: Engineered Microenvironments for Safety and Efficacy Testing contains chapters from world-leading researchers in the field of organ on a chip development and applications, with perspectives from life sciences, medicine, physiology and engineering. The book contains an overview of the field, with sections covering the major organ systems and currently available technologies, platforms and methods. As readers may also be interested in creating biochips, materials and engineering best practice, these topics are also described. Users will learn about the limitations of 2D in-vitro models and the available 3D in-vitro models (what benefits they offer and some examples). Finally, ...
1001 Children's Books You Must Read Before You Grow Up is the perfect introduction to the very best books of childhood: those books that have a special place in the heart of every reader. It introduces a wonderfully rich world of literature to parents and their children, offering both new titles and much-loved classics that many generations have read and enjoyed. From wordless picture books and books introducing the first words and sounds of the alphabet through to hard-hitting and edgy teenage fiction, the titles featured in this book reflect the wealth of reading opportunities for children.Browsing the titles in 1001 Children's Books You Must Read Before You Grow Up will take you on a journey of discovery into fantasy, adventure, history, contermporary life, and much more. These books will enable you to travel to some of the most famous imaginary worlds such as Narnia, Middle Earth, and Hogwart's School. And the route taken may be pretty strange, too. You may fall down a rabbit hole, as Alice does on her way to Wonderland, or go through the back of a wardrobe to reach the snowy wastes of Narnia.
The consensus is clear - climate change is the defining challenge of our time. Meeting this challenge requires a collaborative and inclusive response from all segments of society - including private businesses. What role then for competition law and policy? This important and timely book gathers academics, enforcers, economists, lawyers, and industry representatives to explore the applications and limitations of EU competition law in achieving environmental sustainability aims in line with the European Commission's Green Deal as well as the UN's Sustainable Development Goals. They identify the challenges of integrating environmental considerations into competition analysis presented by the existing framework, whether through cooperation by businesses, practices by dominant companies, or consideration of sustainability efficiencies in merger assessments. Practical examples across various sectors are also provided, alongside agency views from different jurisdictions, to illustrate how competition policy can facilitate a sustainable economy.
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Global in scope and transdisciplinary in method, this work examines the process through which local historic landscapes become global heritage sites. The Valtellina, a valley in the Italian Alps, is known for being unusually fertile for its elevation and latitude, and for the dry stone terraces on its steep hillsides that make this fertility possible. ProVinea, a local nonprofit, has applied to UNESCO to inscribe these landscapes onto its World Heritage list, representing the construction and use of the terraces as the heroic transformation of barren slopes into fertile fields. Drawing on Michel Serres’ theory of serial parasitism, this study demonstrates how ProVinea discursively and materially remakes the landscapes by culling the advantageous, eliminating the detrimental, and assembling the dispersed. A casualty of this process is a more complex and complete truth, one that this book aims to restore, while also acknowledging the validity of World Heritage’s efforts to build a global culture and ProVinea’s desire to connect to it.