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Protein Chromatography
With its focus on process development and large-scale bioseparation tasks, this is tailor-made reading for the professional bioengineer in both the biotech and pharmaceutical industries. Following a tried-and-tested concept, this guide has been developed over several years in training courses for biotech and chemical engineers in Europe and the U.S. The first part deals with the theory, introducing chromatography and its dynamics, as well as discussing mass transfer and dispersion effects. The second part then goes on to cover equipment and protocols, determining the retention factor and HETP from isocratic and elution experiments, as well as the mass transfer and intraparticle diffusivity from batch and shallow-bed adsorption experiments.
Protein Chromatography
An all-in-one practical guide on how to efficiently use chromatographic separation methods Based on a training course that teaches the theoretical as well as practical aspects of protein bioseparation to bioprocess professionals, this fully updated and revised new edition offers comprehensive coverage of continuous chromatography and provides readers with many relevant examples from the biopharmaceutical industry. Divided into two large parts, Protein Chromatography: Process Development and Scale-Up, Second Edition presents all the necessary knowledge for effective process development in chromatographic bioseparation, both on small and large scale. The first part introduces chromatographic t...
Mediterranean Marine Avifauna
May I first congratulate, inconditionally, the Association MEDMARAVIS for organizing this symposium and for inviting me re presenting the Sardinian Ministry of the Environment. I would like to assert that such initiatives help a great deal and in a concrete way, Heads of government departments in charge of land use and natural resources. At this first symposium of the Mediterranean Marine Avifau na I must congratulate the scientific faculty for proposing such an ample spectrum of high quality papers dealing with diverse parts of the Mediterranean and beyond. I am sure that their con tributions will further scientific research, will help to pro tect our environment and will lead, more especially, to the ma nagement and conservation of seabirds. To know in order to manage has often been said at this sym posium. In fact, it is not possible to manage thoughtfully and rationally the natural resources without knowing more profound ly how they function. This reasoning is also valid on a more ge neral scale: regional planning of human activities should not disregard the evaluation of the ecosystem.
Chromatographic and Membrane Processes in Biotechnology
Separation processes in biotechnology are of increasing industrial importance since they entail the major costs of bioprocessing especially when high purity is required. Chromatography and membranes are two of the most important technologies used for direct treatment of fermentation broths as well as for high resolution steps in product purification. The theoretical foundations of chromatographic and membrane processes are well understood for the case of small molecules. Nevertheless there is a need to adapt and further develop that knowledge to the processing of large biological molecules. This is being achieved with the contribution of other areas like molecular biology and materials scien...
Carbohydrate Chemistry: State Of The Art And Challenges For Drug Development - An Overview On Structure, Biological Roles, Synthetic Methods And Application As Therapeutics
The structural complexity and the synthetic challenges facing glycans have historically hampered efforts to study their multifaceted roles and the application of carbohydrates in drug development. However, in very recent years, new synthetic techniques flanked by the growing knowledge about carbohydrate involvement in physiological and pathological states has spurred renewed interest in the chemistry, biology and therapeutic potentialities of carbohydrates. This book offers an overview of key aspects of carbohydrate biology and chemistry that are fundamental for the design of novel therapeutics. The four-part structure of this book introduces these essential components to life, starting from...
Plasticity of Cold Worked Metals
Plasticity theory is a tool used in structural analysis to evaluate the ultimate strength and the post-elastic behavior of ductile structures, explains Paglietti (strength of metals and engineering, U. of Cagliari, Italy), but its application to real materials is undermined by the evolution law of the yield surface, also known as the work-hardening
Thermomechanics & Infrared Imaging, Inverse Problem Methodologies and Mechanics of Additive & Advanced Manufactured Materials, Volume 6
Thermomechanics & Infrared Imaging, Inverse Problem Methodologies and Mechanics of Additive & Advanced Manufactured Materials, Volume 6 of the Proceedings of the 2022 SEM Annual Conference & Exposition on Experimental and Applied Mechanics, the sixth volume of six from the Conference, brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on a wide range of areas, including: Test Design and Inverse Method Algorithms Inverse Problems: Virtual Fields Method Material Characterizations Using Thermography Fatigue, Damage & Fracture Evaluation Using Infrared Thermography Residual Stress Mechanics of Additive & Advanced Manufactured Materials
Process Validation in Manufacturing of Biopharmaceuticals
The fourth edition of Process Validation in Manufacturing of Biopharmaceuticals is a practical and comprehensive resource illustrating the different approaches for successful validation of biopharmaceutical processes. A pivotal text in its field, this new edition provides guidelines and current practices, contains industrial case studies, and is expanded to include in-depth analysis of the new Process Validation (PV) guidance from the US FDA. Key Features: Offers readers a thorough understanding of the key concepts that form the basis of a good process validation program for biopharmaceuticals. Includes case studies from the various industry leaders that demonstrate application of these conc...
Parties and Elections in Europe
"Parties and Elections in Europe" is a comprehensive reference guide to the parliamentary elections and governments in the European countries since 1945, the elections to the European Parliament since 1979 and to all significant political parties in Europe. Listed are more than 1250 parties (currently active parties and dissolved or inactive parties). The guide includes basic data of these parties (founding years, political orientations, affiliations to political parties at European level, political groups in the European Parliament and political internationals) and a chronological summary of their history (name changes, predecessors, mergers and splits).
