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Dendritic Cells
The understanding of the role of dendritic cells (DCs) in immune responses has come a long way since Steinmann and colleagues described these cells in 1972. - tensive research during the intervening period has provided a good understanding of the complexity of the DC system and its pivotal role in immunity. It is also now clearer how different subsets of DCs interact and regulate each other and how DC populations affect the function of other cells of the immune system. The improved understanding of their role in immune response has led to the idea that modulation of DC functions by, for example, pharmacological agents could be used as a pot- tial therapeutic approach in some pathological con...
Searching for Immune Tolerance Manipulating New Molecules and Exploiting New Concepts on Lymphocyte Biology
The break on immune tolerance is a common point between autoimmune diseases and the uncontrolled effector immune responses against allo-antigens in transplantation. Among the past years, several approaches to restore a suppressive immune state have included the targeting of co-stimulatory/inhibitory molecules on immune cells, the promotion or blockade of pivotal cytokines, and the extensive study on how to isolate and expand suppressive cells with the purpose to re-infuse them in patients. To date, the availability of new technologies has permitted to learn, in a more detailed way, the immune mechanisms carried out by suppressive lymphocytes, together with the identification of new potential...
Regulatory T-Cells
This volume provides methods and models for investigating the immunosuppressive subset of CD4+ T-cells, regulatory T-cells (Treg). Chapters guide readers through, basic protocols for analyzing Treg in mice and humans, single-cell analysis for analyzing Treg, and methods for the analysis of Treg in clinical application. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Regulatory T-Cells: Methods and Protocols aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.
The Immunological Barriers to Regenerative Medicine
This volume offers an analysis of the scale and nature of the immunological issues facing regenerative medicine, drawing on the expertise of laboratories around the world who have taken up the challenge of applying their expertise in immunology to the vagaries of stem cell biology. In Part I, we explore the extent to which the principles of allograft rejection, learned over several decades from our experiences of whole organ transplantation, apply within the unique context of cell replacement therapy. Part II discusses various innovative ways of addressing the issues of immunogenicity, while, in Part III, we focus exclusively on the induction of immunological tolerance through a variety of novel approaches. It is our hope that this systematic analysis of the current state of the field will galvanise efforts to solve an issue which has so far remained intractable.
Analyzing the Role of Citizen Science in Modern Research
As the need for sustainable development practices around the world continues to grow, it has become imperative for citizens to become actively engaged in the global transition. By evaluating data collected from various global programs, researchers are able to identify strategies and challenges in implementing civic engagement initiatives. Analyzing the Role of Citizen Science in Modern Research focuses on analyzing data on current initiatives and best practices in citizen engagement and education programs across various disciplines. Highlighting emergent research and application techniques within citizen science initiatives, this publication appeals to academicians, researchers, policy makers, government officials, technology developers, advanced-level students and program developers interested in launching or improving citizen science programs across the globe.
Ambitious Form
Ambitious Form describes the transformation of Italian sculpture during the neglected half century between the death of Michelangelo and the rise of Bernini. The book follows the Florentine careers of three major sculptors--Giambologna, Bartolomeo Ammanati, and Vincenzo Danti--as they negotiated the politics of the Medici court and eyed one another's work, setting new aims for their art in the process. Only through a comparative look at Giambologna and his contemporaries, it argues, can we understand them individually--or understand the period in which they worked. Michael Cole shows how the concerns of central Italian artists changed during the last decades of the Cinquecento. Whereas their...
Translating tolerogenic therapies to the clinic – where do we stand and what are the barriers?
This Research Topic is a call for papers to provide an up to date assessment of current attempts to introduce tolerogenic therapies into clinical practice. Tolerance has been a highly sought after goal in the field of organ transplantation for over half a century, and is now readily achievable in rodent models, but considerable barriers remain to successfully translating tolerogenic treatments to the clinic. The initial call for this Research Topic has been aimed to provide an overview of recent advances made within the European RISET and American ITN networks with regard to tolerogenic strategies in clinical transplantation, autoimmune disease, and allergy. Articles will also cover the barr...
The Year 3000
First published in 1897, The Year 3000 is the most daring and original work of fiction by the prominent Italian anthropologist Paolo Mantegazza. A futuristic utopian novel, the book follows two young lovers who, as they travel from Rome to the capital of the United Planetary States to celebrate their “mating union,” encounter the marvels of cultural and scientific advances along the way. Intriguing in itself, The Year 3000 is also remarkable for both its vision of the future (predicting an astonishing array of phenomena from airplanes, artificial intelligence, CAT scans, and credit cards to controversies surrounding divorce, abortion, and euthanasia) and the window it opens on fin de siècle Europe. Published here for the first time in English, this richly annotated edition features an invaluable introductory essay that interprets the intertextual and intercultural connections within and beyond Mantegazza’s work. For its critical contribution to early science fiction and for its insights into the hopes, fears, and clash of values in the Western world of both Mantegazza’s time and our own, this book belongs among the visionary giants of speculative literature.
