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NK Cell Subsets in Health and Disease: New Developments
Natural Killer (NK) cells were discovered ca 1975, as the first group of lymphoid cells that were neither T cells nor B cells. Since then, the dissection of the biology of NK cells has been growing exponentially with many seminal discoveries from the identification of MHC class I-specific inhibitory receptors to the discovery of receptor-ligand pairs involved in NK cell activation and to the manipulation of NK cells in cancer. In this research topic, we asked a group of thought leaders in NK cell biology to review recent advances in their origins and biology, and their roles in cancer, infection and inflammation. Together, these 25 articles provide a timely survey of NK cells as critical immunologic components of health and disease. They will hopefully prompt further dialogue and developments in basic and translational immunology.
The Crisis of Détente in Europe
This edited volume is the first detailed exploration of the last phase of the Cold War, taking a critical look at the crisis of détente in Europe in the late 1970s and early 1980s. The transition from détente to a new phase of harsh confrontation and severe crises is an interesting, indeed crucial, phase of the evolution of the international system. This book makes use of previously unreleased archival materials, moving beyond existing interpretations of this period by challenging the traditional bipolar paradigm that focuses mostly on the role of the superpowers in the transformation of the international system. The essays here emphasize the combination and the interplay of a large number of variables- political, ideological, economic and military - and explore the topic from a truly international perspective. Issues covered include human rights, the Euromissiles, the CSCE (Commission on Security and Cooperation in Europe), the Revolution in Military Affairs, economic growth and its consequences.
Cell Migration in Inflammation and Immunity
Chemokines and their receptors play a central role in the pathogenesis of numerous, perhaps all, acute and chronic inflammatory diseases. About 50 distinct chemokines produced by a variety cell types and tissues either c- stitutively or in response to inflammatory stimuli are involved in a plethora of biological processes. These small secreted proteins exert their exquisitely variegated functions upon binding to a family of seven-transmembrane spanning G-protein coupled receptors (GPCRs) composed of almost 20 distinct entities. The biological activities of chemokines range from the control of leukocyte trafficking in basal and inflammatory conditions to the regulation of hema- poiesis, angio...
Bionanocatalysis: From Design to Applications
Bionanocatalysis: From Design to Applications discusses recent advances in nano-biocatalysis, fundamental design concepts and their applications in a variety of industry sectors. Strategies for immobilizing enzymes onto nanocarriers, made from polymers, silicas, carbons, and metals, by physical adsorption, covalent binding, cross-linking, or specific ligand spacers are also discussed as are the advantages, problems and solutions derived from the use of non-porous nanomaterials for enzyme immobilization. This is an important reference source for materials scientists and chemical engineers who would like to learn more about how nanobiocatalysts are designed and used. Biocatalysis has emerged a...
The Routledge Handbook of Transatlantic Security
This new Handbook provides readers with the tools to understand the evolution of transatlantic security from the Cold War era to the early 21st century. After World War II, the US retained a strong presence as the dominant member of NATO throughout the Cold War. Former enemies, such as Germany, became close allies, while even countries that often criticized the United States made no serious attempt to break with Washington. This pattern of security co-operation continued after the end of the Cold War, with NATO expansion eastwards extending US influence. Despite the Iraq war prompting a seemingly irreparable transatlantic confrontation, the last years of the Bush administration witnessed a w...
Italy in the International System from Détente to the End of the Cold War
This edited collection offers a new approach to the study of Italy’s foreign policy from the 1960s to the end of the Cold War, highlighting its complex and sometimes ambiguous goals, due to the intricacies of its internal system and delicate position in the fault line of the East-West and North-South divides. According to received opinion, during the Cold War era Italy was more an object rather than a factor in active foreign policy, limiting itself to paying lip service to the Western alliance and the European integration process, without any pretension to exerting a substantial international influence. Eleven contributions by leading Italian historians reappraise Italy’s international role, addressing three complex and intertwined issues, namely, the country’s political-diplomatic dimension; the economic factors affecting Rome’s international stance; and Italy’s role in new approaches to the international system and the influence of political parties’ cultures in the nation’s foreign policy.
Perforating the Iron Curtain
Cold War history research of the recent years suggests that the East-West detente process of the 1970s was a more significant element than previously believed in understanding and explaining the processes, on both sides of the East-West divide, which led to the peaceful end of the Cold War in the late 1980s. This anthology is a contribution to this research. The dozen articles elucidate the European detente process from grass-root - as well as diplomatic - levels, including the Helsinki Conference Final Act of 1975 on respect of human rights and human contacts across the Iron Curtain of the Cold War. The articles are based on recently opened state and private archives from West and East Europe, as well as the US. They are written by a mix of internationally distinguished senior scholars and younger promising researchers from the US, Germany, Poland, Switzerland, Italy, and Denmark.
The Italian State and International Terrorism, 1969–1986
This book sheds light on the so-called ‘Moro Doctrine’, an Italian state security policy which has been portrayed in literature as an under-the-counter agreement made between Italy and Palestinian movement during the Cold War. The Moro Doctrine, or ‘Lodo Moro’ as it is known in Italy, aimed to protect the peninsula from Palestinian attacks by allowing terrorists to use Italian territory as a base for weapons and guerrilla fighters. Responsibility for the ‘Lodo’ was instrumentally placed on Aldo Moro, the five- time Prime Minister of Italy, after his death, and since then his name has become indelibly linked with the shame of having negotiated with Palestinian terrorists. Thanks t...
China's European Headquarters
Ariane Knüsel offers new perspectives on China's presence in Europe through analysis of Switzerland's central role during the Cold War.
West Germany and Israel
A new history of the West German-Israeli relationship as these two countries faced terrorism, war, and economic upheaval in a global Cold War environment.
