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Preservation of Human Oocytes
Oocyte cryopreservation entails important potential advantages for humanIVF, offering a less ethically disputable alternative to embryo cryopreservation,simplifying and making safer oocyte donation, and giving an opportunity forfertility preservation to women at risk of premature ovarian failure as an effectof genetic factors or chemo- or radiother
Oogenesis
The oocyte is the largest and most mysterious cell in the body of mammalian organisms. Through its growth and maturation, it reaches extreme levels of specialization, while maintaining at the same time a condition of totipotency. Its unique ability, in co-operation with the spermatozoon, to give rise to a fully developed organism formed from hundreds of different tissues and myriads of individual cells has inspired intellectuals of all ages. Oogenesis finds impetus and purpose in casting scientific perspective towards this unique cell for the benefit of scientists and assisted reproductive technology (ART) specialists. The authors of the chapters are distinguished authorities in their respective areas of competence. From the opening of the book the reader is lead on a fantastic voyage from the formation of the primordial oocyte to the development of the early embryo, passing through crucial processes of oogenesis, such as co-ordination of oocyte and follicle growth, gene expression and organelle reorganization during growth and maturation, epigenetic mechanisms, regulation of meiosis, totipotency, cell polarity, oogenesis in vitro and maternal regulation of early development.
In Vitro Fertilization
Now in its revised and expanded second edition - including over 20 new chapters - this comprehensive textbook remains a unique and accessible description of the current and developing diagnostic and treatment techniques and technologies comprising in vitro fertilization (IVF). Arranged thematically in sections, each chapter covers a key topic in IVF in a sensible presentation. Parts one and two describe the planning, design and organization of an ART unit and IVF laboratory and equipment and systems, respectively. The sections that follow provide detailed descriptions of IVF techniques, embryo culture methods, sperm processing and selection, insemination procedures, micromanipulation, embryo...
Manual of Embryo Selection in Human Assisted Reproduction
Selecting the best embryo to transfer to the uterus is key to successful in vitro fertilization (IVF). A huge amount of research has been devoted to this topic and there are numerous methods used, from simple morphological assessment to molecular biological techniques to assess the genome and metabolism of the newly fertilized embryo. For many of these techniques, an adequate evidence base is lacking, and expert opinion is valuable. Clinical imperatives require ranking all embryos in a cohort according to their viability, thereby enabling the selection of the best embryo to optimize live birth outcome: a key indicator used to measure and rate IVF Clinics worldwide. This clear and informative manual will provide embryologists and clinicians with an overview of the tools now available to assist in embryo selection, as well as evidence for their efficacy and safety and the broader considerations that must underlie these important clinical decisions.
Quality Control in the Assisted Reproductive Technology Laboratory
This guide provides an overview of quality control in ART laboratories. It explores frameworks and essential tools necessary for effective quality management. The fields of monitoring, equipment maintenance, and the intricate aspects of embryo care and cryopreservation are thoroughly examined. The significance of the ART lab witnessing system is highlighted, demonstrating the seamless integration of both manual and electronic witnessing tools. Readers will gain insights into the roles played by KPIs and SOPs. For aspiring embryologists, this guide offers an exploration of training techniques, addressing the inherent challenges of the field. Practical coping strategies are provided to help navigate these stressors successfully. With real-world case studies and discussions on laboratory design, this resource serves as a guide to achieving excellence in ART. It emphasizes the importance of balancing patient care, procedural accuracy, and practitioner well-being.
Stem Cells in Human Reproduction
Following a successful first edition, this new book updates the revolutionary advances in stem cell science that may potentially impact human reproductive medicine. The contents cover the production and regeneration of female and male germ cells, trophoblasts and endometrium from human embryonic and adult stem cells. New developments in hESC d
Infertility in Practice, Fourth Edition
The field of infertility research and practice is one of continuous innovation and change, but alongside the increasing sophistication of assisted reproductive techniques there is as strong a need as ever for clinical experience and expertise and common practical sense to inform diagnosis and clinical decision making. Now in its fourth edition, Infertility in Practice is practical and gives the clinician a clear picture of the aetiology of infertility and a careful assessment of the basis for treatment options. A thoroughly comprehensive book that provides sound theory and evidence based therapy, this book is a must for any practitioner dealing with infertility.
Motherhood on Ice
Answers the question: Why are women freezing their eggs? Why are women freezing their eggs in record numbers? Motherhood on Ice explores this question by drawing on the stories of more than 150 women who pursued fertility preservation technology. Moving between narratives of pain and empowerment, these nuanced personal stories reveal the complexity of women’s lives as they struggle to preserve and extend their fertility. Contrary to popular belief, egg freezing is rarely about women postponing fertility for the sake of their careers. Rather, the most-educated women are increasingly forced to delay childbearing because they face a mating gap—a lack of eligible, educated, equal partners re...
Textbook of Assisted Reproductive Technologies
Textbook of Assisted Reproductive Technologies is a truly comprehensive manual for the whole team at the IVF clinic. Information is presented in a highly visual manner, allowing both methods and protocols to be consulted easily. The text provides clinical and scientific teams with the A to Zs of setting up an embryology laboratory, gives research fellows insight into technical developments, and supplies seasoned professionals with a review of the latest techniques and advances. New to the Third Edition: fully revised and expanded chapters, with new information on: single embryo transfer artificial gametes pharmacogenetics
