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Naked Genes
The interaction between new forms of biological life and new forms of social life in modern democracies.
Stem Cell Epigenetics
Growing evidence suggests that epigenetic mechanisms play a central role in stem cell biology and are vital for determining gene expression during cellular differentiation and governing mammalian development. In Stem Cell Epigenetics, leading international researchers examine how chromatin regulation and bona fide epigenetic mechanisms underlie stem cell renewal and differentiation. Authors also explore how the diversity of cell types, including the extent revealed by single cell omic approaches, is achieved, and how such processes may be reversed or managed via epigenetic reprogramming.Topics discussed include chromatin in pluripotency, stem cells and DNA methylation, histone modifications ...
Bacterial Artificial Chromosomes
For both volumes: Expert investigators describe not only the classic methods, but also the many novel techniques they have perfected for the transfer of large DNAs into the cells of both microbes and animals via large-insert recombinant DNAs. Volume 1 presents readily reproducible techniques for library construction, physical mapping, and sequencing.. An accompanying volume, Volume 2: Functional Studies, provides a wide variety of methods and applications for functional analysis of the DNA-transformed organisms. Besides protocols, each chapter includes scientific reviews, software tools, database resources, genome sequencing strategies, and illustrative case studies.
Reframing Rights
Investigations into the interplay of biological and legal conceptions of life, from government policies on cloning to DNA profiling by law enforcement. Legal texts have been with us since the dawn of human history. Beginning in 1953, life too became textual. The discovery of the structure of DNA made it possible to represent the basic matter of life with permutations and combinations of four letters of the alphabet, A, T, C, and G. Since then, the biological and legal conceptions of life have been in constant, mutually constitutive interplay—the former focusing on life's definition, the latter on life's entitlements. Reframing Rights argues that this period of transformative change in law ...
The Benefit of Broad Horizons
More than perhaps anybody else in the world, the Swedish social scientist Björn Wittrock has contributed - both on the intellectual and institutional level - to making a truly global science possible. This book is devoted to an appreciation of his contributions.
Innate Immunity
Immunologists today are interested in all of the diverse cell-types involved in host defense and have a deeper appreciation of the importance of innate immune mechanisms as a first line of protection against pathogens. This volume thus discusses the isolation and functional characterization of cells involved in innate immunity in mouse and man, including mast cells and eosinophils. Other focuses include natural killer cells, methods in statistics, in vivo imaging, genome engineering, and mutagenesis and culture that are adapted to the study of innate immunity in these hosts. These are complemented with a series of chapters dealing with alternative models: plants, worms, mosquitoes, flies, and fish. Together, these approaches and models are being used to dissect the complex interplay between hosts and pathogens and contribute to developing strategies to help fight infection. With chapters written by experts on the cutting-edge of this technology, Innate Immunity is an essential reference for immunologists, histologists, geneticists, and molecular biologists.
Science Fiction and Futurism
Science and science fiction have become inseparable--with common stories, interconnected thought experiments, and shared language. This reference book lays out that relationship and its all-but-magical terms and ideas. Those who think seriously about the future are changing the world, reshaping how we speak and how we think. This book fully covers the terms that collected, clarified and crystallized the futurists' ideas, sometimes showing them off, sometimes slowing them down, and sometimes propelling them to fame and making them the common currency of our culture. The many entries in this encyclopedic work offer a guided tour of the vast territories occupied by science fiction and futurism. In his Foreword, David Brin says, "Provocative and enticing? Filled with 'huh!' moments and leads to great stories? That describes this volume."
Philosophy of Systems Biology
The emergence of systems biology raises many fascinating questions: What does it mean to take a systems approach to problems in biology? To what extent is the use of mathematical and computational modelling changing the life sciences? How does the availability of big data influence research practices? What are the major challenges for biomedical research in the years to come? This book addresses such questions of relevance not only to philosophers and biologists but also to readers interested in the broader implications of systems biology for science and society. The book features reflections and original work by experts from across the disciplines including systems biologists, philosophers,...
Opera and Sovereignty
Performed throughout Europe during the 1700s, Italian heroic opera, or opera seria, was the century’s most significant musical art form, profoundly engaging such figures as Handel, Haydn, and Mozart. Opera and Sovereignty is the first book to address this genre as cultural history, arguing that eighteenth-century opera seria must be understood in light of the period’s social and political upheavals. Taking an anthropological approach to European music that’s as bold as it is unusual, Martha Feldman traces Italian opera’s shift from a mythical assertion of sovereignty, with its festive forms and rituals, to a dramatic vehicle that increasingly questioned absolute ideals. She situates ...
Naturalism in the Philosophy of Health
In a series of papers published in the 1970s, Christopher Boorse proposed a naturalist theory of health, mainly based on a value-free concept of ‘biological function’, a concept of ‘reference class’ and the notion of ‘statistical normality’. His theory has profoundly shaped the philosophical debates on the concepts of health and disease. It could even be said that the numerous criticisms of his 'biostatistical theory' are at the centre of what is usually referred to as the debate between ‘normativists’ and ‘naturalists’. Today, the predominant naturalist theory of health is still Boorse’s biostatistical theory. This volume offers the first comprehensive review and criti...
