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The book, intended for biomedical researchers, attempts to foster a comprehensive understanding of the elements that impact scientific research, such as clinical trial design, communication, and publication methods. It introduces the process of idea generation and creative/critical thinking, leading to the development of key concepts that coalesce into theoretical constructs and working hypotheses. The book systematically delineates research phases associated with a bench-to-bedside translational approach, providing the full depth and breadth of drug discovery and development: design, synthesis, and optimization of drug candidates interacting with targets linked to diseases, as well as clini...
The present book covers the basic principles of cardiovascular physiology, pathophysiology and advanced pharmacology with particular emphasis on cellular mechanisms of drug action. It provides an update on the progress made in several aspects of cardiovascular diseases so that it might kindle scientists and clinicians alike in furthering basic and translational research. In addition, the book is expected to fill imperative gaps in understanding and optimally treating cardiovascular disease.
This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.
Specially designed for aspiring researchers, this book presents a systematic exposition of the basic principles and methodologies involved in biomedical research. The book covers the entire research process from the conception of an idea, its development, investigation and execution and finally to its publication. Various research methodologies including study design and statistical approaches to data analysis are also discussed in detail. The importance of ethics and integrity in research is highlighted extensively. In addition, the book discusses relevant issues relating to the commercialization of research innovations and outlines the steps necessary for successful entrepreneurship.
A guide for parents to help children of all ages process the onslaught of unfiltered information in the digital age. Education is not solely about acquiring information and skills across subject areas, but also about understanding how and why we believe what we do. At a time when online media has created a virtual firehose of information and opinions, parents and teachers worry how students will interpret what they read and see. Amid the noise, it has become increasingly important to examine different perspectives with both curiosity and discernment. But how do parents teach these skills to their children? Drawing on more than twenty years’ experience homeschooling and developing curricula, Julie Bogart offers practical tools to help children at every stage of development to grow in their ability to explore the world around them, examine how their loyalties and biases affect their beliefs, and generate fresh insight rather than simply recycling what they’ve been taught. Full of accessible stories and activities for children of all ages, Raising Critical Thinkers helps parents to nurture passionate learners with thoughtful minds and empathetic hearts.
РАСТИТЕЛЬНАЯ ЕДА – это продукты, полученные без использования мяса, молока, яиц, рыбы и морепродуктов. В принципе это веганство, но WFPB (Whole-Food, Plant-Based) диета предполагает использование в пищу только либо цельных продуктов, либо минимально обработанных, без добавления соли, масел и сахара.Многие продукты, используемые в этой диете, представляют собой полезные альтернативы обычных п...
Kinder und Jugendliche sind heute ständig online und bestens vernetzt. Am laufenden Band prasseln ungefiltert Informationen auf sie ein. Dabei stehen sie unter anderem vor der enormen Herausforderung, Nachrichten von Meinungen zu unterscheiden und Vorurteile oder Fake News zu entlarven. Viele Eltern stellen sich dabei die Frage, wie sie ihren Kindern am besten helfen können, sicher durch den Informationsdschungel zu navigieren. Die erfahrene Pädagogin Julie Bogart weiß: In unserem digitalen Zeitalter ist es wichtiger denn je, zu verstehen, wie wir von außen beeinflusst werden und warum kritisches Denken so entscheidend ist. Anhand zahlreicher konkreter Tipps und Übungen für jedes Alter zeigt Julie Bogart Ihnen, wie Sie Ihre Kinder dabei begleiten, zu selbstbewussten und kritisch denkenden Persönlichkeiten zu werden.
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