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Developmental programming is a rapidly advancing discipline of great importance to basic scientists and health professionals alike. This text integrates, for the first time, contributions from world experts to explore the role of the placenta in developmental programming. The book considers the materno-fetal supply line, and how perturbations of placental development impact on its functional capacity. Chapters examine ways in which environmental, immunological and vascular insults regulate expression of conventional and imprinted genes, along with their impact on placental shape and size, transport, metabolism and endocrine function. Research in animal models is integrated with human clinical and epidemiological data, and questions for future research are identified. Transcripts of discussions between the authors allow readers to engage with controversial issues. Essential reading for researchers in placental biology and developmental programming, as well as specialists and trainees in the wider field of reproductive medicine.
This book had its beginning in 1967 when Shirley G. Driscoll and Kurt Benirschke wrote in English the volume on placental pathology for the Henke-Lubarsch, the noted German Handbook of Pathology. There seemed to be a need for wider distribution of the text and it was reprinted by Springer Verlag, New York, essentially the only book available devoted just to the human placenta. Dr. Benirschke authored 5 subsequent editions in collaboration with Peter Kaufmann, Rebecca Baergen and Graham Burton in 1990 (2nd edition), 1995 (3rd edition), 2000 (4th edition), 2006 (5th edition) and 2012 (6th edition). In the early editions, the most important material was in a larger font than the extensive revie...
Developmental programming is a rapidly advancing discipline of great importance to basic scientists and health professionals alike. This text integrates, for the first time, contributions from world experts to explore the role of the placenta in developmental programming. The book considers the materno-fetal supply line, and how perturbations of placental development impact on its functional capacity. Chapters examine ways in which environmental, immunological and vascular insults regulate expression of conventional and imprinted genes, along with their impact on placental shape and size, transport, metabolism and endocrine function. Research in animal models is integrated with human clinical and epidemiological data, and questions for future research are identified. Transcripts of discussions between the authors allow readers to engage with controversial issues. Essential reading for researchers in placental biology and developmental programming, as well as specialists and trainees in the wider field of reproductive medicine.
Deliver academic presentations with confidence Collins English for Academic Purposes: Presenting gives you the skills you need to plan, prepare and deliver successful presentations at college or university. Learn how to feel confident and relaxed when presenting in seminars or tutorials prepare concise and effective notes keep your audience interested anticipate problems Collins English for Academic Purposes: Presenting will help you to make the most of your time at university. Clear information and practice exercises, with chapters on seminars, tutorials and poster presentations Audio CD with model language and effective presentation techniques Information on academic expectations - underst...
The present volume of the book series Advances in Anatomy, Embryology and Cell Biology brings together current reviews from leading experts to address the diversity of placentation by which species establish and maintain pregnancy. Development of viviparity and placentation in rodents, dogs, pigs, cattle, horses, marsupials, primates and elephants are discussed. The development of viviparity in mammals, including some invertebrate species, required the adaptation of the placenta to serve as a functional conduit for interplay between the semiallograftic fetus with the maternal uterus. Although the ‘placenta’ protects the fetus from maternal immune rejection and provides oxygen and nutrien...
Natural Killer (NK) cells are innate lymphocytes, now recognized as members of a larger family of “Innate lymphoid cells” (ILCs). Both murine and human NK cells are well characterized effector cells with cytotoxic as well as cytokine production ability which mainly react in response to microbial and cell stress stimuli, thus playing a central role in the defense against pathogen infection, in tumor surveillance and in regulating immune homeostasis. Despite these established concepts, our understanding of the complexity of NK cells, also in view of their developmental and functional relationship with other ILC subsets, is only recently emerging. This Research Topic highlights the recent advances in NK cell (and ILC) research in human and mouse from basic research to clinical applications.
The Oxford Textbook of Obstetrics and Gynaecology is an objective and readable text that covers the full speciality of obstetrics and gynaecology. This comprehensive and rigorously referenced textbook will be a vital resource in print and online for all practising clinicians. Edited by a team of four leading figures in the field, whose clinical and scientific backgrounds collectively cover the whole spectrum of obstetrics and gynaecology with particular expertise in fetomaternal medicine and obstetrics, gynaecological oncology, urogynaecology, and reproductive medicine, the textbook helps inform and promote evidence-based practice and improve clinical outcomes worldwide across all facets of ...
The 3rd edition, the first new one in ten years, includes coverage of molecular levels of detail arising from the last decade's explosion of information at this level of organismic organization. There are 5 new Associate Editors and about 2/3 of the chapters have new authors. Chapters prepared by return authors are extensively revised. Several new chapters have been added on the topic of pregnancy, reflecting the vigorous investigation of this topic during the last decade.The information covered includes both human and experimental animals; basic principels are sought, and information at the organismic and molecular levels are presented. *The leading comprehensive work on the physiology of reproduction*Edited and authored by the world's leading scientists in the field*Is a synthesis of the molecular, cellular, and organismic levels of organization*Bibliogrpahics of chapters are extensive and cover all the relevant literature
The overall scope of this new series will be to evolve an understanding of the genetic basis of (1) how early mesoderm commits to cells of a heart lineage that progressively and irreversibly assemble into a segmented, primary heart tube that can be remodeled into a four-chambered organ, and (2) how blood vessels are derived and assembled both in the heart and in the body. Our central aim is to establish a four-dimensional, spatiotemporal foundation for the heart and blood vessels that can be genetically dissected for function and mechanism. Since Robert DeHaan's seminal chapter "Morphogenesis of the Vertebrate Heart" published in Organogenesis (Holt Rinehart & Winston, NY) in 1965, there hav...