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New edition of an authoritative, practical account, incorporating the latest thinking on the biology of the disease and the best practice in its management. The author works in Jamaica, where the sickle cell trait affects 10% of the population, and he is gratified to report on the significant advances that have been made in the six years since the first edition of his text. Annotation copyright by Book News, Inc., Portland, OR
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In this thoroughly revised and updated second edition, a panel of distinguished clinical researchers from around the world takes stock of the wealth of new knowledge about the human spleen and applies it to the pathology and treatment of splenic diseases. This much enriched understanding encompasses the spleen's complex role in immunological defense, the recently defined function of particulate filtration by the spleen, and the structural basis for the functions of the spleen, most particularly the microvasculature around which it is organized. Among the diseases and disorders of the spleen considered in detail are splenomegaly, the consequences and management of hyper- and hyposplenism, and "dilutional anemia." Recent advances in splenic surgery are also reviewed, especially those techniques intended to preserve at least partial function while removing the greater part of the organ.
First multi-year cumulation covers six years: 1965-70.
An observational study infers the effects caused by a treatment, policy, program, intervention, or exposure in a context in which randomized experimentation is unethical or impractical. One task in an observational study is to adjust for visible pretreatment differences between the treated and control groups. Multivariate matching and weighting are two modern forms of adjustment. This handbook provides a comprehensive survey of the most recent methods of adjustment by matching, weighting, machine learning and their combinations. Three additional chapters introduce the steps from association to causation that follow after adjustments are complete. When used alone, matching and weighting do not use outcome information, so they are part of the design of an observational study. When used in conjunction with models for the outcome, matching and weighting may enhance the robustness of model-based adjustments. The book is for researchers in medicine, economics, public health, psychology, epidemiology, public program evaluation, and statistics who examine evidence of the effects on human beings of treatments, policies or exposures.
Although more is known about sickle cell disease than about any other inherited disease, no cure for it exists. In America alone, about one in 375 who are of African ancestry is born with sickle cell disease. A smaller number of Americans descended from families from the Mediterranean area, the Middle East, and India also are affected. In addition, about eight percent of black Americans who do not suffer from the disease itself carry the gene for it that can be transmitted to their children. Sickle cell disease is of enormous biological, social, and historic importance. It was first described in medical literature almost a century ago. Improvements during the past two decades in our understa...
In 2018, the first genetically modified children were born. Now we have the tools to reshape the future of our species. With a pair of genetic scissors known as CRISPR, we can select the traits of our children, avoid ageing, or cure disease. With that ability comes new risks, forcing us to face hard ethical questions. Torill Kornfeldt has travelled the world to meet the people driving this research forward. She has visited fertility clinics in South Korea, oncologists in China who are experimenting on sick patients, and biohackers in the US who want to make the new technology available to everyone. In The Unnatural Selection of Our Species, she asks: How can we handle these new tools that co...