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Liposome Technology
Although the role of liposomes in drug targeting has been discussed extensively in several reviews and books, there has been no comprehensive coverage of related methodology. This book constitutes the first attempt to put together all aspects of lipsome technology as applied to medical sciences. Volume III is devoted to the growing variety of techniques yielding targeted liposomes and to approaches of studying liposomal behaviour in the biological milieu both in vitro and in vivo.
Liposome Technology
Although the role of liposomes in drug targeting has been discussed extensively in several reviews and books, there has been no comprehensive coverage of related methodology. This book constitutes the first attempt to put together all aspects of lipsome technology as applied to medical sciences. Volume II describes procedures for the entrapment of a number of drugs, including genetic material, into selected types of lipsomes.
Liposome Technology
Liposome Technology, Volume I: Liposome Preparation and Related Techniques, Third Edition, is a thoroughly updated and expanded new edition of a classic text in the field. Including step-by-step technical details, Volume I illustrates numerous methods for liposome preparation and auxiliary techniques necessary for the stabilization and characteriza
Liposomes as Drug Carriers
Sixty contributions on liposomes and their uses in drug delivery. Conventional use of drugs suffers from indiscriminate drug action leading to side effects; failure of drugs to reach areas in need of pharmacological intervention; and premature drug inactivation and secretion. This book describes how liposomes incorporating drugs can direct these to diseased areas (in isolation from non-target biological areas) and introduce drugs to areas otherwise inaccessible. Discusses the interaction of liposomes with the biological milieu in vitro and in vivo, ways of optimizing liposomal behavior by manipulation of the carrier, applications related to antimicrobial and cancer therapy, vaccines, enzyme therapy, metal detoxification, diagnostics, and more.
Targeting of Drugs
Successful drug use in biology and medicine is often prejudiced by the failure of drugs that are otherwise active in vitro to act as efficiently in vivo. This is because in the living animal drugs must, as a rule, bypass or traverse organs, membranes, cells and molecules that stand between the site of administration and the site of action. In practice, however, drugs can be toxic to normal tissues, have limited or no access to the target and be prematurely excreted or inactivated. There is now growing optimism that such problems may be resolved by the use of carrier systems that will not only protect the non-target environment from the drugs they carry but also deliver them to where they are needed or facilitate their release there. Carrier systems presently under investigation include antibodies, glycoproteins, cells, reconstituted viruses and liposomes. Recent advances in the chemistry of cell receptor and receptor-recognising molecules, llnmunology, and natural and artificial membranes have revealed a multitude of ways in which such carrier systems can be modified or improved upon.
Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines
This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants.
Artificial and Reconstituted Membrane Systems
This collection of 11 chapters is devoted to a survey of artificial and reconsti tuted membrane systems. These are fundamental themes and areas of great current importance in membrane biochemistry. They also relate well to the founding concept of this series, namely, to present studies that progressively work toward and provide us with an "integrated view of the cell. " In this volume, it is the application of a wide range of physiochemical and biochemi cal techniques to the study of membrane lipids and proteins which serves to demonstrate the significant progress that has been made in this field over the past 25 years. From the understanding of simplified artificial systems, it is hoped tha...
Biomedical Applications of Immobilized Enzymes and Proteins
I) ADSORPTION EEEEEEEE E E carrier 2) COVALENT LINKAGE a) Insoluble support b) Intermolecular linkage N'E~ ~~ c) Soluble support 0 \:)....m 3) tM TRIX (MOLECULAR) ENTRAPMENT ~~~~~;;..,J~-polymer matrix 4) ENCAPSULATION membrane FIGURE I. Classification of immobilized enzymes. Covalently linked, adsorbed, and matrix-entrapped enzymes represent stage II, research on the microenvironment. Microencapsulation represents stage III, research on the intracellular environment. Further subdivision of microencapsulated enzymes will be found in Chapter 12. 4 T. M. S. CHANG matrix entrapment. In this section, detailed discussions will center on clinical analysis, urine analysis, monitoring of environment...
Vaccine Design
Proceedings of a NATO ASI held in Cape Sounion, Greece, June 24-July 5, 1996
Biomembranes
Membrane research holds a central position in cell and molecular biology. In recent years it has become clear that the study of membranes at the molecular level is of great importance not only to decipher all cellular processes but also to understand the alterations leading to abnormal cells (including cancer cells) and/or to understand the action of various drugs. This book covers the multidisciplinary approach of research in this area and the permanent need for information regarding recent advances. It will serve both workers studying basic aspects of membrane structure and function as well as medically oriented scientists. The selection of topics illustrating interconnections between basic and applied membrane biology will cross-fertilize research in both groups.
