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Ultra-High Performance Liquid Chromatography and Its Applications
Explores both the benefits and limitations of new UHPLC technology High performance liquid chromatography (HPLC) has been widely used in analytical chemistry and biochemistry to separate, identify, and quantify compounds for decades. The science of liquid chromatography, however, was revolutionized a few years ago with the advent of ultra-high performance liquid chromatography (UHPLC), which made it possible for researchers to analyze sample compounds with greater speed, resolution, and sensitivity. Ultra-High Performance Liquid Chromatography and Its Applications enables readers to maximize the performance of UHPLC as well as develop UHPLC methods tailored to their particular research needs...
Handbook of Modern Pharmaceutical Analysis
Handbook of Modern Pharmaceutical Analysis, Second Edition, synthesizes the complex research and recent changes in the field, while covering the techniques and technology required for today's laboratories. The work integrates strategy, case studies, methodologies, and implications of new regulatory structures, providing complete coverage of quality assurance from the point of discovery to the point of use. - Treats pharmaceutical analysis (PA) as an integral partner to the drug development process rather than as a service to it - Covers method development, validation, selection, testing, modeling, and simulation studies combined with advanced exploration of assays, impurity testing, biomolecules, and chiral separations - Features detailed coverage of QA, ethics, and regulatory guidance (quality by design, good manufacturing practice), as well as high-tech methodologies and technologies from "lab-on-a-chip" to LC-MS, LC-NMR, and LC-NMR-MS
Chiral Separation Methods for Pharmaceutical and Biotechnological Products
Discusses chiral separations and offers guidance for selecting the optimum method for desired results Chiral separations represent the most intriguing and, by some measures, most difficultseparations of chemical compounds. This book provides researchers and students an under-standing of chiral separations and offers a convenient route to selecting the best separation method, saving considerable time and cost in product development. Considering chiral separations in the biotechnological and pharmaceutical industries, as well as for food applications, Dr. Ahuja provides insights into a broad range of topics. Opening with a broad overview of chiral separations, regulatory considerations in drug...
Serious Things
In the early 1990s, at an old-fashioned boarding school, two boys form an intense friendship that will shape the course of their lives. Bruno Jackson, the shy and lonely son of British expats, is infatuated by the glamorous but troubled Anthony Blunden. Taken under the wing of an idealistic English teacher, the boys are encouraged to explore the 'more serious things' of life beyond college. But in the hothouse of the school, a slight from their mentor seems of earth-shattering importance, with fateful consequences. Years later, with the memories of that time almost buried, Bruno leads a blameless, uneventful life. The sudden reappearance of Anthony forces him to revisit the dark corners of his past and to decide how far he's prepared to go to assuage his conscience. From the acclaimed writer of GHOST PORTRAIT and THE SHIP OF FOOLS, this is a gripping tale of vengeance, morality and the complex paths that can lead to redemption.
Society and Exploitation Through Nature
Society and Exploitation Through Nature offers an integrated approach to the environment, linking the philosophical, social and physical sciences to environmental problems and issues. The text covers three main themes; exploitation of nature and society; the limits of exploitation through sustainability and managing environmental problems. These themes are illustrated throughout the book with global case studies.
Say Not to Say
This text explores the major ways in which miscommunication can be experienced in our daily life.
Acid Rain in Europe
The environmental impacts of acid rain: on human health, on buildings and materials, on forests, freshwaters, crops and biodiversity and on global warming have been well-documented. Less is known about the extent and economic costs of these impacts. This book describes the first major implementation of an integrated scientific and economic assessment of the consequences of acid rain. It provides an extensive data review and examines how this unique approach to assessment modelling can be can be used to calculate an acidification cost per unit of pollutant in monetary terms. Part One focuses on the methodological issues of scientific measurement of acidification, dose-response relationships and economic approaches to acidification control. Part Two looks at the environmental impacts and economic consequences of acidification. Affected environmental media and human health are investigated in separate chapters, each including both scientific and economic analyses. Part Three provides a summary of the findings and makes recommendations for further application of these types of results to policy actions.
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Poorly Soluble Drugs
This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis-à-vis their physical and chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as for the fulfillment of regulatory obligations with respect to biopharmaceutical assessment and product quality understanding. The percentage of poorly soluble drugs, defined in classes 2 and 4 of the Biopharmaceutics Classification System (BCS), has significantly increased in the moder...
