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Chemistry and Biology of Pteridines and Folates
Pteridine and folate research has long been recognized as important for many biological processes, such as amino acid metabolism, nucleic acid synthesis, neurotransmitter synthesis, cancer, cardiovascular function, and growth and development of essentially all living organisms. Defects in synthesis, metabolism and/or nutritional availability of these compounds have been implicated as major causes of common disease processes, e.g. cancer, inflammatory disorders, cardiovascular disorders, neurological diseases, autoimmune processes, and birth defects. Since pteridine and folate biology uses concepts and experimental techniques drawn from all of these disciplines, the breadth of this volume is its great strength, bringing together researchers from a wide variety of fields including biochemistry, chemistry, physics, biophysics, genetics, microbiology, cell and molecular biology, virology, immunology, cancer, neurobiology and medicine. This volume should be a valuable and unique reference work for scientists with interests in these areas as well as those seeking up to date information.
Recovery from Brain Damage
It has long been recognized that damage to the mammalian central nervous system may be followed by behavioral recovery, but only re cently has close attention been directed to specific factors which may enhance or retard restitution. This is evident in the rapidly growing number of journal articles and scientific paper sessions dealing with "recovery of function," as well as in the publicity given by the popular press to some of the findings in this field. The present text seeks to examine the foundations of brain lesion research, to review recent material on a number of factors which ap pear to contribute to recovery after brain damage, and to present mod els which have been proposed to account for these effects. In order to best accomplish these goals, a number of key workers in these areas were asked to examine and describe research literatures dealing with specific problems or methodological manipulations associated with brain damage and behavior, using their own experiments and those of others to illustrate important points. In addition, significant interpre tive and theoretical issues were to be evaluated in each chapter.
Chemistry and Biology of Pteridines and Folates
The pteridines in their multitude of forms fulfill many roles in nature ranging from pigments to cofactors for numerous redox and one-carbon transfer reactions. This extraordinary diversity of function is unified by the unique chemistry of the pteridine heterocycle. The International Symposium on the Chemistry and Biology of Pteridines and Folates is a forum for presenting recent and exciting advances in this expanding field. In of ideas results that has often stimulated bringing together various disciplines, a synergy fresh approaches to major problems. The Tenth International Symposium held at Orange Beach, Alabama, March 21-23, 1993, proved no exception by providing new insights into fola...
Scientific Directory and Annual Bibliography
Each issue lists papers published during the preceding year.
Debating Cancer: The Paradox In Cancer Research
Cancer research is at a crossroads. Traditionally, cancer has been thought of as a disease of gene mutation, where the stepwise accumulation of cancer gene mutations is the key, and the identification of common gene mutations has been considered to be essential for diagnosis and treatment. Despite extensive research efforts and accumulated knowledge on cancer genes and pathways, the clinical benefits of this traditional approach have been limited. Recently, cancer genome sequencing has revealed an extensive amount of genetic heterogeneity where the long-expected common mutation drivers have been difficult, if not impossible, to identify. These realities ultimately challenge the conceptual framework of current cancer biology.This book introduces a new concept of genome theory of cancer evolution, in an attempt to unify the field. Many important and representative, but often confusing, questions and paradoxes are critically analyzed. By comparing gene- and genome-based theories, the hidden flaws of many popular viewpoints are addressed. This discussion is intended to initiate a much-needed critical re-evaluation of current cancer research.
Effects of Foods and Drugs on the Development and Function of the Nervous System
Abstract: A collection of papers presented at an FDA symposium describes the influences of foods and drugs on thedevelopment and functioning of nervous systems. Neurobehavioral development and maintenance include both neurobiological and neurochemical development of the brain and are affected by nutritional influences. Methods for assessing neurotoxicity and current status of neurotoxicity screening procedures are described. Specific research is detailed briefly. Finally, current issues in neurotoxicity such as food colors, amino acids, vitamins and megavitamins,drug/diet interaction, nutrients as drugs, dietary control of behavior, anticonvulsant drugs, and fetal alcohol syndrome are discussed. (rkm).
Catecholamine Research
This book is based on invited presentations at the Ninth International Catecholamine Symposiwn. Over several decades, each International Catecholamine Symposiwn (ICS) has provided a uniquely important forwn for updating basic as well as clinical research on the catecholamines, dopamine, norepinephrine, and epinephrine. The first ICS took nd n1 place in Bethesda, Maryland, in the USA in 1958; the 2 in Milan, Italy in 1965; the 3 th in Strasbourg, France in 1973; the 4th in Asilomar, California, USA in 1978; the 5 in th th Goteborg, Sweden in 1983; the 6 in Jerusalem, Israel,in 1987; the 7 in Amsterdam, th Netherlands in 1992; and the 8 in Asilomar, California, USA in 1996. th The 9 Internatio...
Published Scientific Papers of the National Institutes of Health
Each issue lists papers published during the preceding year.
Catecholamines
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