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The human genome encompasses ˜ 860 G protein-coupled receptors (GPCRs) including 374 non-chemosensory GPCRs. Half of these latter GPCRs recognize (neuro)peptides as natural ligands. GPCRs thus play a pivotal role in neuroendocrine communication. In particular, GPCRs are involved in the neuroendocrine control of feeding behavior, reproduction, growth, hydromineral homeostasis and stress response. GPCRs are also major drug targets and hence possess a strong potential for the development of innovative pharmaceuticals. The aim of this Research Topic was to assemble a series of review articles and original research papers on neuropeptide GPCRs and their ligands that would illustrate the different facets of the studies currently conducted in this domain.
Since the early 20th century, animated Christmas cartoons have brightened the holiday season around the world--first in theaters, then on television. From devotional portrayals of the Nativity to Santa battling villains and monsters, this encyclopedia catalogs more than 1,800 international Christmas-themed cartoons and others with year-end themes of Hanukkah, Kwanzaa and the New Year. Explore beloved television specials such as A Charlie Brown Christmas, theatrical shorts such as Santa's Workshop, holiday episodes from animated television series like American Dad! and The Simpsons, feature films like The Nutcracker Prince and obscure productions such as The Insects' Christmas, along with numerous adaptations and parodies of such classics as A Christmas Carol and Twas the Night before Christmas.
This book covers quantum chemical simulation of molecular systems and their quantum chemical properties, alongside the most cutting-edge biomedical applications.
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