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Phenotypic screening in the 21st century
In the genomic era of 1990s-2000s, pharmaceutical research moved to target-based drug discovery which enabled development of a number of small molecule drugs against a wide range of diseases. In many cases however, drugs that arose from genomics failed, questioning the validity of the targets and the suitability of target-based drug discovery as an optimal strategy for all disease states. For monogenic diseases, target-based approaches may be well-suited to the identification of novel therapies. Most diseases, however, are caused by a combination of several genetic and environmental factors and are likely to require simultaneous modulation of multiple molecular targets/pathways for successfu...
Medicinal Plants used in Traditional Persian Medicine
Medicinal plants and the natural products within them, still remain the starting point for breakthroughs in the development of safe, pharmacologically active synthetic molecules for use in a wide variety of clinical situations. Traditional Persian Medicine (TPM) is one of the most ancient medical doctrines, and is well-documented in terms of information about diseases, diagnoses and treatments, especially in the application of medicinal plants. TPM has been used for centuries worldwide, and many of these methods are still used in Iran today. The book introduces the basics of TPM, and describes the key medicinal plants used for the treatment of different diseases. It also highlights possible new targets for research activities in drug discovery of natural products. The book is richly illustrated with historic drawings from old Persian pharmacopoeia and photos of plants in their natural habitats. Reference to Ayurvedic, Traditional Chinese Medicine and monastic medicine in Europe are also made. This book provides a valuable, evidence-based resource on TPM for researchers, practitioners and students in medicinal plants, ethnobotany and herbal medicine.
Nutricines and Derivatives of Nutrients in Animal Health and Disease Prevention
Good animal health is of great importance for the efficient production of animal-derived foods at a low cost. The demand for solutions for animal health maintenance and disease prevention is a major global challenge in animal production, food safety, and public health. The animal body has a complete self-defense system, including oxidation and anti-oxidation balance, immune activation and suppression balance, pro- and anti-inflammatory balance, which can help the host against various factors that endanger normal life activities. Nowadays, the strategy of nutrition-based health has become an increasingly important solution for animal health maintenance and disease prevention. Nutrients (carbohydrates, fats, proteins, minerals, vitamins, et al.) and nutricines (carotenoids, enzymes, fatty acids, flavors, oligosaccharides, organic acids, phospholipids, polyphenols, et al.) are two major categories of components in feeds. Nutricines and some derivatives of nutrients (vitamin derivatives, amino acid derivatives, et al.) have been intensively studied in animal and cell culture models, and their roles in animal health maintenance and disease prevention are intimately known.
Gönül Işığı
Bu Kitaptaki metinlerin büyük bir kısmı ülkemizin seçkin sanat ve edebiyat dergilerinde, büyük bir kısmı da “Gönül Sitesi” isimli web sitemizde yayınlanmış düşünce yazıları ve edebi metinlerdir. Bu incelikli metinler duyumsamalarımızı, dokunmalarımızı hissettiren cümlelerden örülüdür. Düşünmeyi öğreten, düşünmenin gücünü gösteren, kelime ve cümlelerin tesirini, yazma ahlakını ifade eden edebi metinlerdir. Gönül ışığıyla aydınlanır kafalar. Hani Mevlânâ; “içinde ışık bulunmayan gönül, gönül değildir” demişti ya. Bu itibarla gönül dünyamızı aydınlatan “Gönül Işığı” adını aldı kitabımız. Bu ışıkla...
Antitargets and Drug Safety
With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future. Divided into three major parts, the first section deals with novel technologies and includes the utility of adverse event reports to drug discovery, the translational aspects of preclinical safety findings, broader computational prediction of drug side-effects, and a description of the serotonergic system. The main part of the book looks at some of the most common antitarget-mediated side effects, focusing on hepatotoxicity in drug safety, cardiovascular toxicity and signaling effects via kinase and GPCR...
Predictive ADMET
This book helps readers integrate in silico, in vitro, and in vivo ADMET (absorption, distribution, metabolism, elimination and toxicity) and PK (pharmacokinetics) data with routine testing applications so that pharmaceutical scientists can diagnose ADMET problems and present appropriate recommendations to move drug discovery programs forward. The book introduces the current clinical practice for drug discovery and development along with the impact on early risk assessment; consolidates the tools and models to intelligently integrate existing in silico, in vitro and in vivo ADMET data; and demonstrates successful cases and lessons learned from real drug discovery and development. In short, it is a book aimed to provide a practical road map for drug discovery and development scientists to generate efficacious and safe drugs for unmet medical needs.
The History of Neuroscience in Autobiography
The seventh volume of The History of Neuroscience in Autobiography is a collection of autobiographical essays by distinguished senior neuroscientists in which they recount the events that shaped their lives and identify the mentors and colleagues who inspired them. The narratives provides a human dimension to the world of scientific research.
Middle Powers in Asia and Europe in the 21st Century
This volume presents three claims regarding the role of middle powers in the 21st Century: first, states aspiring to become or remain middle powers choose from three possible role: to be a global middle powers; to be a regional pivot; or to be a niche leader. Second, states seeking such roles need different mixes of hard and soft power sources. Third, more so than great or small powers, middle powers walk a thin line between the domestic and systemic pressures they face. In this volume, these claims are based on (comparative) case studies of Germany, Iran, Italy, Japan, the Netherlands, Norway, South Korea, Sweden, and Turkey.
