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ABOUT THE BOOK The Book is an interdisciplinary textbook, written with the intent of introducing two new concepts. A. The Association Constant (Ka) versus Entropy and Chaos. 1. The formation and evolution of chemical and biological compounds on atomic and molecular scales are the work of the four natural forces, enhanced by the existence of the natural constants and their remarkable adjustment. And the work of the covalent and noncovalent forces (bonds) being derived from the natural forces. So is the evolution of living organisms but with the essential and indispensable impact of the environment, violent and punctuate. 2. The effects of the natural forces (through the covalent and noncovale...
Among the various mycotoxins affecting man, OTA -- involved in the renal disease endemic in the Balkans -- is thought by the International Cancer Research Centre (ICRC) to be a potential carcinogen. The question facing the international ochratoxin-A specialists was whether endemic renal disease in the Balkans was still restricted to this geographical region. A careful study of human ochratoxicosis and other possibly associated pathologies in under-developed countries could enable future developments of the problems to be forecast in other parts of the globe and hence allow means of preventive action to be sought.
Biological Roles and Function of Modification
Modified Nucleosides in Cancer and Normal Metabolism - Methods and Applications
The story of a scientific controversy: the case of "memory of water". A true scientific thriller with detailed descriptions of disputed experiments performed by the French immunologist Jacques Benveniste; with many details of the famous conflict with the scientific journal Nature and its Director John Maddox. www.mille-mondes.fr
The Discovery of Ribonuclease P and Enzymatic Activity of Its RNA Subunit Sydney Brenner and Francis H. C. Crick had a specific project in mind when they offered Sidney Altman a position in their group in 1969 to conduct postdoctoral research at the Medical Research Council Laboratory of Molecular Biology (LMB) in Cambridge, England. At the time, an intense international competition was on- ing in as many as a dozen labs to determine the three-dimensional structure of tRNA. At the LMB, Aaron Klug was attacking the structure by crystallographic analysis with Brian F. C. Clark providing large amounts of purified phenylalanine tRNA. (Eventually, Aaron announced his empirically determined 3-D st...
Yeast is one of the oldest domesticated organisms and has both industrial and domestic applications. In addition, it is very widely used as a eukaryotic model organism in biological research and has offered valuable knowledge of genetics and basic cellular processes. In fact, studies in yeast have offered insight in mechanisms underlying ageing and diseases such as Alzheimers, Parkinsons and cancer. Yeast is also widely used in the lab as a tool for many technologies such as two-hybrid analysis, high throughput protein purification and localization and gene expression profiling. The broad range of uses and applications of this organism undoubtedly shows that it is invalubale in research, technology and industry. Written by one of the world's experts in yeast, this book offers insight in yeast biology and its use in studying cellular mechanisms.