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Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis
The human foetus is separated from the maternal blood by the syncytiotrophoblast induced by endogeneous human retrovirus-encoded proteins. This barrier is a highly developed one, which suppors apical-basolateral transport of maternal idiotype and anti-idiotype IgG, IgG-virus complexes. The selective maternal-fetal transport of epitope- and paratope-bearing entities can influence the developping fetal immune system during pregnancy. The bidirectional maternal-fetal transfer of cells are of even more importance during pregnancy. Maternal cells with latent viruses transport viruses without impairment of fetal development. Cells with premaligant and malignant genetic transformation are also transported to the fetus. Fetal and neonatal tumours are initiated by such cells in spite of the antitumour potential of fetal organism. On the contary, the fetal cells repair maternal tissue injouries and survive in the organisms of the recipients for decades. These possess new consequences for the neonatal immunity and organ transplatation surgery.
Science-Based Bioethics
This book has two primary aims, to analyze how advancing scientific discoveries uncover or elicit bioethical concerns and challenges and to provide the essential scientific background and bioethical information that allows scientists, healthcare professionals and clinical researchers to better comprehend, appreciate and address the complex bioethical dilemmas that our society confronts.
RNA/DNA and Cancer
In this book, the author Joseph G. Sinkovics liberally shares his views on the cancer cell which he has been observing in vivo and in vitro, over a life time. Readers will learn how, as an inherent faculty of the RNA/DNA complex, the primordial cell survival pathways are endogenously reactivated in an amplified or constitutive manner in the multicellular host, and are either masquerading as self-elements or as placentas, to which the multicellular host is evolutionarily trained to extend full support. The host obliges. The author explains that there is no such evidence that “malignantly transformed” human cells survive in nature. However, when cared for in the laboratory, these cells liv...
Polio Across the Iron Curtain
Through the lens of polio, Dóra Vargha looks anew at international health, communism and Cold War politics. This title is also available as Open Access.
Parasites
An exciting look at the essential roles that parasites play in Earth’s ecosystems This book looks at the weird and wonderful world of parasites, the most abundant form of life on Earth. Parasites come in all forms and sizes and inhabit every free-living organism. Parasitism is now, and always has been, a way to survive under changing environmental conditions. From arctic oceans to tropical forests, Scott Gardner, Judy Diamond, and Gabor Racz investigate how parasites survive and evolve, and how they influence and provide stability to ecosystems. Taking readers to the open ranges of Mongolia, the Sandhills of north-central Nebraska, the Andes of Bolivia, and more, the authors examine the im...
Cord Blood
In this book, the authors discuss cord blood banks and banking, the ethical issues involved and the risks and benefits. Topics include the virological risks and benefits of cord blood banking; mesenchymal stem cells and their role in regenerative medicine applications; osteogenic potential of human umbilical cord-derived mesenchymal stromal cells; public versus private cord blood banking; CCR5 deficient cord blood as a means of treatment for HIV-1 infection; and the therapeutic use of umbilical cord blood.
