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New Experimental Probes for Enzyme Specificity and Mechanism
New Experimental Probes for Enzyme Specificity and Mechanism, Volume 685, the latest release in the Methods of Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics including Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis, New Mechanistic Probes to Identify Novel Substrates for N-Myristoyltransferases, Phosphonate and a Fluorophosphonate Analogues of D Glucose 6 Phosphate as Active-Site Probes of 1L-Myo-Inositol 1 phosphate Synthase, Kinetic Mechanism of Nicotine-Degrading Enzyme Probed by Stopped-Flow Kinetic Analyses, Kinetics and Mechanism for Enzyme-Catalyzed Reactions of Subs...
Virtual Drug Design
In the current drug research environment in academia and industry, cheminformatics and virtual screening methods are well established and integrated tools. Computational tools are used to predict a compound’s 3D structure, the 3D structure and function of a pharmacological target, ligand-target interactions, binding energies, and other factors essential for a successful drug. This includes molecular properties such as solubility, logP value, susceptibility to metabolism, cell permeation, blood brain barrier permeation, interaction with drug transporters and potential off-target effects. Given that approximately 40 million unique compounds are readily available for purchase, such computational modeling and filtering tools are essential to support the drug discovery and development process. The aim of all these calculations is to focus experimental efforts on the most promising candidates and exclude problematic compounds early in the project. In this Research Topic on virtual activity predictions, we cover several aspects of this research area such as historical perspectives, data sources, ligand treatment, virtual screening methods, hit list handling and filtering.
Urban Images of the Hispanic World, 1493-1793
This fascinating book examines the particular importance of cities in Spanish and Hispanic-American culture as well as the different meanings that artists and cartographers invested in their depiction of New and Old Wold cities and towns. Kagan maintains that cities are both built human structures and human communities, and that representations of the urban form reflect both points of view. He discusses the peculiar character of Spain's empire of towns; the history and development of the cityscape as an independent artistic genre, both in Europe and the Americas; the interaction between European and native mapping traditions; differences between European maps of urban America and those produced by local residents, whether native or creole; and the urban iconography of four different New World towns. Lavishly illustrated with a variety of maps, pictures, and plans, many reproduced here for the first time, this interdisciplinary study will be of interest to general readers and to specialists in art history, cartography, history, urbanism, and related fields.
