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Systems Biology of Microbial Infection
The systems biology of microbial infections aims at describing and analysing the confrontation of the host with bacterial and fungal pathogens. It intends to understand and to model the interaction of the host, in particular the immune system of humans or animals, with components of pathogens. This comprises experimental studies that provide spatio-temporal data from monitoring the response of host and pathogenic cells to perturbations or when interacting with each other, as well as the integrative analysis of genome-wide data from both the host and the pathogen. In perspective, the host-pathogen interaction should be described by a combination of spatio-temporal models with interacting mole...
The Numerical Solution of Integral Equations of the Second Kind
This book provides an extensive introduction to the numerical solution of a large class of integral equations.
The Films of Stan Brakhage in the American Tradition of Ezra Pound, Gertrude Stein and Charles Olson
Since the late 1950s Stan Brakhage has been in the forefront of independent filmmaking. His body of work — some seventy hours — is one of the largest of any filmmaker in the history of cinema, and one of the most diverse. Probably the most widely quoted experimental filmmaker in history, his films typify the independent cinema. Until now, despite well-deserved acclaim, there has been no comprehensive study of Brakhage’s oeuvre. The Films of Stan Brakhage in the American Tradition fills this void. R. Bruce Elder delineates the aesthetic parallels between Brakhage’s films and a broad spectrum of American art from the 1920s through the 1960s. This book is certain to stir the passions of those interested in artistic critique and interpretation in its broadest terms.
The Birth of Numerical Analysis
The 1947 paper by John von Neumann and Herman Goldstine, OC Numerical Inverting of Matrices of High OrderOCO ( Bulletin of the AMS, Nov. 1947), is considered as the birth certificate of numerical analysis. Since its publication, the evolution of this domain has been enormous. This book is a unique collection of contributions by researchers who have lived through this evolution, testifying about their personal experiences and sketching the evolution of their respective subdomains since the early years. Sample Chapter(s). Chapter 1: Some pioneers of extrapolation methods (323 KB). Contents: Some Pioneers of Extrapolation Methods (C Brezinski); Very Basic Multidimensional Extrapolation Quadratu...
Brakhage Scrapbook
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Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Volume 2
Fungi produce many chemically diverse secondary metabolites whose biological roles largely remain elusive. Within the increasing number of sequenced fungal genomes several important genes involved in secondary metabolite formation have been identified. Most of these genes are clustered and their coordinated transcription is controlled in a complex way by both narrow pathway-specific regulators as well as broad global transcription factors responsive to environmental cues. In recent years it was discovered many of the newly identified gene clusters are silent under laboratory conditions suggesting that the biosynthetic potential of fungi is far from being exploited. Besides identifying nov...
Human Fungal Pathogens
Whereas plant and insect infections are commonly caused by fungi, only a small minority of the vast diversity of fungal species is pathogenic to humans. Despite this, fungal infections cause considerable morbidity and mortality worldwide. This volume is dedicated to the biology, clinical presentation and management of invasive fungal infections. Major pathogenic fungi are introduced by world-leading experts and the basic principles of fungal virulence are reviewed in the light of new results and experimental technologies that offer unprecedented insights into invasive infections caused by Aspergillus, Candida, Cryptococcus, Pneumocystis and Mucorales. In parallel, the clinical presentation of invasive fungal infections and current approaches to their diagnosis and treatment are summarized to provide an overview of human pathogenic fungi, linking pathogen biology to the clinical presentation of disease.
An Introduction to the Mathematical Theory of Inverse Problems
This book introduces the reader to the area of inverse problems. The study of inverse problems is of vital interest to many areas of science and technology such as geophysical exploration, system identification, nondestructive testing and ultrasonic tomography. The aim of this book is twofold: in the first part, the reader is exposed to the basic notions and difficulties encountered with ill-posed problems. Basic properties of regularization methods for linear ill-posed problems are studied by means of several simple analytical and numerical examples. The second part of the book presents two special nonlinear inverse problems in detail - the inverse spectral problem and the inverse scatterin...
Mathematical Methods for Curves and Surfaces
This volume constitutes the thoroughly refereed post-conference proceedings of the 8th International Conference on Mathematical Methods for Curves and Surfaces, MMCS 2012, held in Oslo, Norway, in June/July 2012. The 28 revised full papers presented were carefully reviewed and selected from 135 submissions. The topics range from mathematical analysis of various methods to practical implementation on modern graphics processing units. The papers reflect the newest developments in these fields and also point to the latest literature.
Conjugate Gradient Type Methods for Ill-Posed Problems
The conjugate gradient method is a powerful tool for the iterative solution of self-adjoint operator equations in Hilbert space.This volume summarizes and extends the developments of the past decade concerning the applicability of the conjugate gradient method (and some of its variants) to ill posed problems and their regularization. Such problems occur in applications from almost all natural and technical sciences, including astronomical and geophysical imaging, signal analysis, computerized tomography, inverse heat transfer problems, and many more This Research Note presents a unifying analysis of an entire family of conjugate gradient type methods. Most of the results are as yet unpublish...
