Welcome to our book review site go-pdf.online!
You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
Cancer-Associated Defects in the DNA Damage Response: Drivers for Malignant Transformation and Potential Therapeutic Targets
For this eBook, and the associated Research Topic in Frontiers in Genetics, entitled: ‘Cancer-associated defects in the DNA damage response: drivers for malignant transformation and potential therapeutic targets’ we have selected 10 papers that each discusses important, yet distinct aspects of the response to DNA damage in normal cells and cancer cells. Using an evolutionary conserved signaling network called the ‘DNA damage response (DDR)’ cells maintain the integrity of their genome, and thus safeguard cellular functioning and the ability to create viably progeny. Initially, the DDR appeared to consist of few linear kinase-driven pathways. However, research over the past decades in...
Grappling with the Multifaceted World of the DNA Damage Response
DNA damage is a major threat to genomic integrity and cell survival. It can arise both spontaneously and in response to exogenous agents. DNA damage can attack most parts of the DNA structure, ranging from minor and major chemical modifications, to single-strand breaks (SSBs) and gaps, to full double-strand breaks (DSBs). If DNA injuries are mis-repaired or unrepaired, they may ultimately result in mutations or wider-scale genome aberrations that threaten cell homeostasis. Consequently, the cells elicit an elaborate signalling network, known as DNA damage response (DDR), to detect and repair these cytotoxic lesions. This Research Topic was aimed at comprehensive investigations of basic and novel mechanisms that underlie the DNA damage response in eukaryotes.
Exploiting DNA Damage Response in the Era of Precision Oncology
Topic Editor Christian Reinhardt has received funding from companies Gilead, and lecture fees from Abbvie, Merck, and AstraZeneca. All other topic editors declare no competing interests with regards to the Research Topic subject.
Systems Biology
Biological signaling pathways dynamically interact with one another to form complex information networks intracellularly, intercellularly, and eventually at the level of the organism. Biology and medicine have conventionally focused on identification and characterization of functional elements in biological signaling pathways. Recently, research in this field has pursued a new approach, systems biology, to understand the dynamics, complexity, and physiological functions of the biological signaling networks. Instead of reductionistic analyses or large-scale studies of biomolecules piece by piece, systems biology emphasizes the need for interdisciplinary methods and analysis of the regulation and operation of information networks at the systems level. The contributors to this book are leading researchers in the rising field of systems biology. Readers will find not only the most recent advances in research, but also the latest information about interdisciplinary methods and related topics.
