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Genome research will certainly be one of the most important and exciting sci- tific disciplines of the 21st century. Deciphering the structure of the human genome, as well as that of several model organisms, is the key to our understanding how genes fu- tion in health and disease. With the combined development of innovativetools, resources, scientific know-how, and an overall functional genomic strategy, the origins of human and other organisms’geneticdiseases can be traced. Scientificresearch groups and dev- opmental departments of several major pharmaceutical and biotechnological companies are using new, innovative strategies to unravel how genes function, elucidating the gene protein pr...
This book focuses on the computational modeling of organometallic reactivity. In recent years, computational methods, particularly those based on Density Functional Theory (DFT) have been fully incorporated into the toolbox of organometallic chemists’ methods. Nowadays, energy profiles of multistep processes are routinely calculated, and detailed mechanistic pictures of the reactions arise from these calculations. This type of analysis is increasingly performed even by experimentalists themselves. The volume aims to connect established computational organometallics with the more recent theoretical and methodological developments applied to this field. This would allow broadening of the simulation scope toward emergent organometallic areas (as ligand design or photoactivated processes), to narrow the gap between calculations and experiments (microkinetic models) and even to discover new reactions (automated methods). Given the broad interest and extensive application that computational methods have reached within the organometallic community, this new volume will attract the interest of both experimental and computational organometallic chemists.
The first volume of this three-volume work reviews the history of efforts to define biblical righteousness. Modern views are engaged and critiqued, from the seminal article (1860) by Ludwig Diestel (God’s righteousness as the agreement of his will and purpose) to others in the theological stream known as the “New Perspective.” Scholars discussed include Walther Eichrodt, Gerhard von Rad, Elizabeth Achtemeier, James D. G. Dunn and N. T. Wright. Other perspectives are also engaged, including H. H. Schmid’s definition of righteousness as conformity to the created order (Weltordnung), John Piper’s view that God’s righteousness is God’s concern for his own glory, and the traditional...
"Alberto Diaspro has been choreographing light's dance for over 20 years, and in Nanoscopy and Multidimensional Optical Fluorescence Microscopy, he has assembled a diverse group of experts to explain the methods they use to coax light to reveal biology's secrets."- From the Foreword by Daniel Evanko, editor, Nature Methods Nanoscopy and Multidimens
This unique book on super-resolution microscopy techniques presents comparative, in-depth analyses of the strengths and weaknesses of the individual approaches. It was written for non-experts who need to understand the principles of super-resolution or who wish to use recently commercialized instruments as well as for professionals who plan to realize novel microscopic devices. Explaining the practical requirements in terms of hardware, software and sample preparation, the book offers a wealth of hands-on tips and practical tricks to get a setup running, provides invaluable help and support for successful data acquisition and specific advice in the context of data analysis and visualization....
This book includes original essays by prominent researchers and practitioners in the field of postal and delivery economics, originally presented at the 29th Conference on Postal and Delivery Economics held online, September 1-3, 2021. The central focus of the book is the short and long-term impact of covid-19 pandemic on the sectors, both from the economic and regulatory perspectives. Other important topics include the unstoppable growth of e-commerce and the implications for delivery market; solutions for the “last mile”, and the associated challenges in terms of sustainability. Chapters also discuss traditional topics for postal and delivery sectors, such as the competitive dynamics in the sector, the business strategies of postal operators, as well as the definition and funding of the Universal Service Obligation. This book will be a useful tool not only for graduate students and professors interested in postal and regulatory economics, but also for postal administrations, consulting firms, and federal government departments.
This book addresses major issues facing postal and delivery services throughout the world. Worldwide, there is currently a considerable amount of interest in postal and delivery economics. The industry is reacting to a state of near crisis and is implementing different drastic changes. The European Commission and member States are still wrestling with the problem of how to implement entry liberalization into postal markets, how to address digital competition, and how to maintain the universal service obligation (USO). The Postal Accountability and Enhancement Act of 2006 in the U.S. has perhaps created and exacerbated the problems faced by USPS. Digitalisation, technological development and ...