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Mg2+ and Excitable Membranes
This volume presents the most recent research findings on the key role played by Mg2+ in the regulation of ion channels in excitable tissue. Contributions describe the multiple actions exerted by Mg2+ on the different types on ion channels controlling nerve and cardiac cell activity. Recent developments in the detection of single ion channel activity provide important insights into the mechanisms of action of Mg2+ at the channel level.
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Calcium Channels
The most comprehensive compendium of information available on calcium channels Calcium channels are a common component of the membranes of a wide range of excitable cells, and their presence is crucial to the functioning of these cells. This book presents a current review of the biophysics, physiology, pharmacology, and clinical role of calcium channels. Chapters discussing the biophysics of calcium channels include topics in ion permeation, channel activation, channel inactivation, and second messenger modulation. The chapters on physiology cover excitation-contraction coupling, excitation-secretion coupling, sensory transduction, regulation of electrical activity, and the regulation of cel...
Inflammation and Epilepsy: New Vistas
This book provides comprehensive information, both for clinicians and scientists, on the basic mechanisms, clinical features, and therapeutic approaches to epilepsy as an inflammatory disease. Inflammation has been for many years considered as an etiologic player (and a therapeutic target) for a specific group of epilepsies. However, it turns out that this concept underestimated the impact of inflammation in seizure disorders. Many accepted therapies for non-inflammatory epilepsies act in part as an inflammatory drug. The CNS actively responds to acute immune challenges by altering body temperature, stimulating the HPA axis, as well as up- and down-regulating specific sympathetic pathways.
Published Scientific Papers of the National Institutes of Health
Each issue lists papers published during the preceding year.
Receptors P1 and P2 as Targets for Drug Therapy in Humans
This book aims to provide a brief update on the functions of purinergic receptors in various systems, in addition to the signaling pathway activated to mediate these functions. We address the influence of hypoxia by modulating the activity of these receptors under physiological and pathophysiological conditions. Additionally, we describe the mechanisms of induction of pain and inflammation in different systems. Finally, the book discusses some of the main bioinformatics tools currently used to improve or discover new prototypes capable of selectively acting on these receptors with estimated parameters of satisfactory solubility and toxicity for possible commercial implementation.
Calcium and Ion Channel Modulation
Cellular neurobiology has been transformed in the past decade by new technologies and fundamental discoveries. One result is an enormous increase in our understanding of how ion channels function in nerve and muscle cells and a widening perspective on the role of ion channels in non-neuronal cell physiology and development. Patch clamp techniques now permit direct observation of the transitions between functional confor mations of individual ion channels in their native membrane. Recombinant DNA techniques are being used to determine the primary structure of ion channel proteins and to test hypotheses about channel conformations, sites of grating and modulation, and the basis of ion selectiv...
