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Laboratory Methods for the Detection of Mutations and Polymorphisms in DNA
The analysis of DNA sequence polymorphisms and mutations is of central importance in understanding biological systems. This book is devoted to the experimental analysis of DNA and presents easy-to-follow protocols. Various techniques from the simple to the highly complex are detailed in this volume, providing a wide spectrum of available methods and practical advice. The methods are described in terms of: History and background Principles and theory Equipment and reagents Protocols Troubleshooting Applications Improvements Results Comparisons with other methods Future prospects and developments This is an essential manual for researchers working in human, animal, or plant molecular genetics and is particularly valuable for hospital and commercial laboratories.
IGovernment
The authors of this incisive study explore the problems of the ongoing digitization of government, such as the creeping loss of data quality, and how citizens and officials must respond to these complications in the coming years. The iGovernment is running full speed on information networks and digitization, but it is also seriously out of step with existing bureaucracies. iGovernment offers an accurate picture of how the digital technologies are shaping modern governments, and also a powerful corrective for the dissonance between technology and organizational management.“This book will be a valuable resource for researchers and scholars seeking to understand the possibilities, dilemmas, and challenges of bringing the Internet and related technologies to center stage in government and public services”—Helen Margetts,University of Oxford
Galectins in Cancer and Translational Medicine
In the post-genomic era, many efforts have been devoted to better understanding the biological information encoded by the cell "glycome" in normal and pathologic conditions. The glycan signature of human cells plays a pivotal role in regulating fundamental biological processes, which are critical for cell physiology and for cancer as well. Galectins (also worded S-type lectins) are an evolutionarily conserved family of endogenous lectins, which bind carbohydrates with high specificity. These molecules, which can be found both intracellularly and in the extracellular milieu, are functionally active in converting glycan-containing information into cell biological programs. This fashionable mec...
The Skin and Gene Therapy
This first comprehensive guide to the novel field of gene therapy in the skin provides insight into the basic principles and methods of gene transfer into the skin and its applications. It enables the understanding of possibilities and implications such as immunization and treatment as well as safety aspects. Gene therapy in dermatology is the avantgarde of a new field in science with a great future for human health.
Hereditary and Familial Colorectal Cancer
This book describes the historical context of colorectal cancer predisposition syndromes and the latest knowledge relating to each of the known hereditary colorectal cancer predisposition syndromes. There is a particular focus on the management of each of these syndromes in turn, including medical and surgical management, cancer surveillance, and screening recommendations. It also explores the workings of specialised hereditary and familial cancer clinics from the perspectives of the various clinicians involved in the running of the service. Multidisciplinary management, universal tumour screening, risk estimation, the obtaining and use of genetic information, and appropriate high-risk population screening and surveillance are also discussed, as are future developments and how these may relate to this exciting and evolving field.
Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile
For the past 40 years, metal-based drugs have been widely used for the treatment of cancer. Cisplatin and follow-up drugs carboplatin (ParaplatinTM) and oxaliplatin (EloxatinTM) have been the gold standard for metallodrugs in clinical settings as antineoplastic agents. While effective, these drugs (either alone or in combination therapy) have faced a number of clinical challenges resulting from their limited spectrum of activity, high toxicity leading to significant side effects, resistance, poor water solubility, low bioavailability and short circulating time. In the past 10 years, various unconventional non-platinum metal-based agents have emerged as a potential alternative for cancer trea...
Functionally Relevant Macromolecular Interactions of Disordered Proteins
Disordered proteins are relatively recent newcomers in protein science. They were first described in detail by Wright and Dyson, in their J. Mol. Biol. paper in 1999. First, it was generally thought for more than a decade that disordered proteins or disordered parts of proteins have different amino acid compositions than folded proteins, and various prediction methods were developed based on this principle. These methods were suitable for distinguishing between the disordered (unstructured) and structured proteins known at that time. In addition, they could predict the site where a folded protein binds to the disordered part of a protein, shaping the latter into a well-defined 3D structure. ...
Photodynamic Therapy
Photodynamic Therapy: From Theory to Application brings attention to an exceptional treatment strategy, which until now has not achieved the recognition and breadth of applications it deserves. The authors, all experts and pioneers in their field, discuss the history and basic principles of PDT, as well as the fundamentals of the theory, methods, and instrumentation of clinical diagnosis and treatment of cancer. Non-oncological applications such as the use of PDT in control of parasites and noxious insects are also discussed. This book serves as a standard reference for researchers and students at all levels, clinical specialists interested in the topic and those in industry exploring new areas for development. A comprehensive exposition of both the theory and application of PDT, this book fills the gaps in the current literature by bringing together both basic understanding of the process of PDT and an expanded vision of its applications.
