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Hydrolytic Enzymes
This newest volume in the impressive New Comprehensive Biochemistry series presents up-to-date discussions of six types of hydrolytic enzyme that are well characterized structurally: aspartic-, cysteins-, and serine-proteinases, carboxypeptidase A, pancreatic ribonuclease A, and the phosphomonoesterases. The emphasis is on molecular mechanisms deduced by crystallographic, kinetic, spectroscopic and molecular genetic studies. The chapters on the various types of proteinases are complemented by others on proteinase inhibitors and intracellular proteolysis. This book will prove valuable to researchers in general biochemistry, particularly those with interest in enzyme mechanism and protein chemistry, and to Honours and Postgraduate students.
Advances in Protein Chemistry
Advances in Protein Chemistry
The Enzymes
The Enzymes
Peptide and Protein Drug Delivery
This reference/text covers fundamentals of peptide and protein drug delivery, including such considerations as synthesis, physical chemistry and biochemistry, analysis, proteolytic and transport constraints, pharmacokinetics, and pharmacodynamics; bioavailability from routes of administration, detai
Cholinesterases and Anticholinesterase Agents
Although the anticholinesterase (anti-ChE) agents have only limited applica tions in therapy, and from the viewpoint of practical significance they are more appropriately classified as toxic compounds or insecticides than as drugs, in their capacity of pharmacological tools they have few equals. The concept of neuro humoral transmission was originally established largely from experiments in which physostigmine, or eserine, was employed to protect acetylcholine (ACh), the trans mitter of the cholinergic nerves, from rapid hydrolytic destruction by acetyl cholinesterase (AChE) and other cholinesterases (ChE's). Since then, a great num ber of additional reversible and irreversible anti-ChE agen...
The Vienna Circle
In Vienna in the 1920s a group of brilliant philosophers, mathematicians, and scientists – led by figures such as Moritz Schlick, Otto Neurath, Rudolf Carnap, and Hans Hahn – gathered to discuss the foundations of science and mathematics. Known as the Vienna Circle, they proposed to practice philosophy in continuity with science; their movement became known as Logical Empiricism. In this highly engaging book, Sahotra Sarkar tells the story of one hundred years of Logical Empiricism, from its beginnings in 1924 to its legacy today. He explains how its ideas, influenced by revolutionary theories of space, time, and causality of that time, led to a quest for a unified theory of science. He ...
