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Molecular Genetics of Drug Resistance
Drug resistance is a growing problem in today's society. Successful drugs are constantly being developed but there is always the risk that a small percent of the drug's target will be immune. These survivors can then lead to a new population, resistant to the action of this drug. New drugs are continuously under development to combat this problem, but these can, in turn, lead to new resistant populations. This problem is universal whether the target is to destroy a deadly virus, or an insect which is ravaging crop production. Development of new drugs is difficult and time consuming so it is of crucial importance that we understand the processes behind drug resistance. "Molecular Genetics of Drug Resistance" forms a vital and timely review of the genetic processes behind drug resistance. Starting with an overview of the area, each chapter focuses on a particular target with important sections on drug resistance in malaria and in cancer. Each chapter has been written by an acknowledged expert in the field and the careful work of the editors has ensured a consistent approach and presentation.
Candida Albicans
Candida, which was discovered more than a century ago as a causative organism of oral thrush, is now thought to potentially infect almost every tissue of the human body. Although we still do not have a safe anti-candida drug, the growing pace of progess of research on Candida albicans holds promise that a breakthrough is imminent. Though many monographs and articles on candida and candidoses have appeared in recent years, they mostly cover the clinical aspects. This particular text, however, explains the more basic features of candida including the molecular genetics, molecular biology and immunology of the cell wall, the molecular basis of morphogenesis and the structure and function of the plasma membrane. The role of anti-candida drugs and their mechanism of action are also discussed.
Chemotherapy of Fungal Diseases
Fungal diseases have been with us from antiquity; interest in the chemo therapy of fungal disease has exploded in the past decade. To plan and pro duce a book on the topic of antifungal chemotherapy has come as a personal challenge - and something of an eye-opener - towards the end of my re search career. A landmark publication which still merits reading is Antifungal Chemotherapy (John Wiley & Sons, Chichester, UK), edited by David Speller, which appeared in 1980. However, the fact that ketoconazole, the first of the modern, orally active, wide-spectrum antifungals, attracted no more than two sentences in it indicates just how far we have come in the 1980s. A steady stream of original paper...
Chemotherapy of Parasitic Diseases
"Have a chew of dulie," said Crubog . . . "What is it?" asked Potter, half-suspiciously. "Seaweed. " "Is it good for the virility? . . . " "And what is the virility?" asked the old man. "Does it make you more attractive to women?" Potier shouted in his ear. "No. " "What is it good for then?" "WortnS. " "Worms?" "Intestinal worms. You'll never again pass a worm if you eat a fistful of dulse first thing in the morning and last thing at night. " "If it's an anthelmintic, I'll try a spot of it," said Potter. - From Bogmail, a novel by Patrick McGinley (1981) With modern techniques of chemical isolation and structure determination, the old distinction between herbal and chemical remedies has larg...
Candida and Candidamycosis
Scientists from 24 countries who participated in the ~ Symposium on Candida and Candidamycosis, 24-28 April 1989, Antalya, Turkey, have made important contributions to a better understanding of Candida and its infections - by their presence, presentations and discussions in the meeting. The Turkish Microbiological Society, organizing the Symposium in the name of the Federation of European Microbiological Societies (FEMS), thanks all participants for realising this important meeting on such an important subject. In this book the full manuscripts of invited and free papers of the meeting are presented. The Editors extend their sincere thanks to all contributors of papers; to FEMS for encouraging and undertaking the arrangements for publication; to Ege University Publishing House for printing; to Plenum Publishing Company for publishing; and to all colleagues and friends who with their help contributed to this book. The Editors wish that this volume would contribute to a better understanding of Candida and its infections by colleagues working and/or interested in mycology and mycotic diseases.
Advances in Virus Research
Advances in Virus Research
Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds
Proceedings of a NATO ASI held in Çesme (Izmir), Turkey, August 27-September 7, 1989.
