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In recent years, human studies have made enormous contributions towards an understanding of the genetic basis of diabetes mellitus; however, most of the experimentation needed for the invention and testing of novel therapeutic approaches cannot be performed in humans. Thus, there is no alternative to appropriate animal models. In Animal Models in Diabetes Research, expert researchers explore the current status of the most important models and procedures in order to provide a timely resource in experimental diabetology. The first half of the volume serves as a comprehensive overview on our current knowledge of the pathogenesis and pathophysiology of diabetes in animal models through a series ...
All living cells are strictly separated from their surroundings by a membranous lipid bilayer. Into these membranes a variety of transport proteins are embedded that ensure the uptake and secretion of various molecules and ions. In order to respond properly to a changing nutrient supply or demand, as well as to external stress factors, cells must be able to adapt both amount and activity of the corresponding transporters. This book provides readers with state-of-the-art knowledge on the various regulatory mechanisms that control transmembrane transporter expression, activity and their subcellular localisation.
After the demise of Prophet Muhammad (PBUH), the Muslims were divided regarding whom they should follow as their political and religious leader. The Sunnis followed the Prophet’s companions whilst the Shias followed the 12 Holy Imams chosen by God. The Shia Imams were from the lineage of Prophet Muhammad (PBUH) from his only surviving daughter, Lady Fatimah (SA). Successive Shia Imams lived amongst the Muslims for generations and guided them to the true Islamic teachings of the Prophet. All of the Shia Imams were respected by the Muslims for their spirituality, divine knowledge, and being the progeny of the Prophet. The Imams were a symbol of resistance against the injustice and oppression of the Umayyads and the Abbasids. As a result, the Imams endured many calamities and hardships. They were harassed, imprisoned, and martyred by the Umayyad and the Abbasid caliphs. This book reviews the lives of these 12 Holy Imams and provides an overview of their religious, social, and political achievements. Please visit our website at www.12shiaimams.com to find more about the Shia Imams including our recent videos.
Dynamic stability of cells is a function of co-ordination and counterbalance between intracellular signalling events. Therefore, the knowledge of those molecules which form signalling cascades or signalling modules is of prime importance in understanding living processes. Signalling proteins, the component members of different cascades, are the focus of intense interest. Protein phosphorylation dephosphorylation is the prevalent mechanism by which signalling molecules transduce their signals.
A new history of North Africa within the Islamic period from the Arab conquest to the present.
IntelCenter's Terrorism Incident Reference (TIR) series of books is designed to provide a professional-level reference resource to intelligence analysts, operators, security professionals, researchers and others working in the counterterrorism field. It provides a chronological breakout of all terrorist and rebel type activity between 2000-2007. The material for the series is drawn from IntelCenter's weekly World s Terrorist Groups - Intel Update (WTG-IU) reports. Reporting is heavily focused on incident type activity, such as bombings, shootings, kidnappings, etc., with some coverage of arrests, threats and other developments. The data contained in each item represents an analyst s best ass...
With each day that passed after the 2003 invasion, the United States seemed to sink deeper in the treacherous quicksand of Iraq's social discord, floundering in the face of deep ethno-sectarian divisions that have impeded the creation of a viable state and the molding of a unified Iraqi identity. Yet as Adeed Dawisha shows in this superb political history, the story of a fragile and socially fractured Iraq did not begin with the American-led invasion--it is as old as Iraq itself. Dawisha traces the history of the Iraqi state from its inception in 1921 following the collapse of the Ottoman Empire and up to the present day. He demonstrates how from the very beginning Iraq's ruling elites sough...
Malaysian Human Rights Report 2017 SUARAM’s Annual Human Rights Report on Malaysia is widely recognized as the most objective, comprehensive and dependable source of information on the state of human rights in Malaysia. It documents the human rights violations of all the fundamental liberties as well as the struggles of human rights defenders that take place in Malaysia during the year. In 2017, Malaysia struggled with growing repression as the 14th General Election approached. With the competition for political dominance, freedom of expression became the victim and there was widespread arrest, detention and prosecution for online comments made on social media, and the silencing of print a...
As the world focuses on the conflict in Iraq, the most important political players in that country today are not the Sunni insurgents. Instead, they are Iraq's Shi'I majority--part of the Middle East's ninety million Shi'I Muslims who hold the key to the future of the region and the relations between Muslim and Western societies. So contends Yitzhak Nakash, one of the world's foremost experts on Shi'ism. With his characteristic verve and style, Nakash traces the role of the Shi'is in the struggle that is raging today among Muslims for the soul of Islam. He shows that in contrast to the growing militancy among Sunni groups since the 1990s, Shi'is have shifted their focus from confrontation to...