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Targeting the DNA Damage Response for Cancer Therapy
This book discusses the latest developments in Poly (ADP-ribose) polymerase (PARP) inhibitor drug development. It focuses on the translational and clinical development of the latest drugs, as well as the evidence for regulatory approval of PARP inhibitors in multiple different molecular subtypes and tumor indications. The most-up-to-date information on basic scientific research on DNA repair pathways and the DNA Damage Response (DDR) is also covered. Every chapter contains insight into the preclinical, translational along with clinical aspects of a specific DDR inhibitor with key and expert opinion points reinforcing the most important concepts detailed to enable the reader to develop a deep understanding of the topic. Targeting the DNA Damage Response for Cancer Therapy comprehensively reviews the application of PARP and other DDR inhibitors across oncology disciplines. Therefore, it is a valuable resource for all medical professionals and researchers who use or who are researching the use of these inhibitors on a day-to-day basis.
The Yellow River
Flowing through the heart of the North China Plain—home to 200 million people—the Yellow River sustains one of China’s core regions. Yet this vital water supply has become highly vulnerable in recent decades, with potentially serious repercussions for China’s economic, social, and political stability. The Yellow River is an investigative expedition to the source of China’s contemporary water crisis, mapping the confluence of forces that have shaped the predicament that the world’s most populous nation now faces in managing its water reserves. Chinese governments have long struggled to maintain ecological stability along the Yellow River, undertaking ambitious programs of canal an...
The Magic Cube of Ancient Chinese Poetry
This book focuses on the linguistic perspective of classical Chinese poetry and its changes and development in diff erent historical periods. It off ers a combination of theoretical analysis and aesthetic appreciation of exemplary poems. The author discusses the following aspects of classical Chinese poetry: the relationships between background and meaning in the interpretation of a poem; how readers can deal with the tangle of linguistic approach and intuitive perception in interpreting poems; the engagement and disengagement of the poet’s thought fl ow with and from the word order of the verse; the tonal and metrical schemes; and the three special features of classical Chinese poetry: th...
Lu Xun and Russia
Based on Lu Xun's works and book collections, this book explores the significant influence of Russian literature, art, and thinking on Lu Xun's thoughts and works. Through the analysis of rich historical materials and literary texts, this book shows the profound influence of Russian literary and artistic resources on Chinese writers, especially on Lu Xun. It delves into Lu Xun's literary and translation concepts, as well as his intellectual and aesthetic views, all of which bear the imprint of Russian culture. The author closely examines notable themes in his works, including nationality, class, the avant-garde, and cosmopolitanism, which offer insight into his overarching historical vision ...
Insights in Neuro-Oncology and Neurosurgical Oncology: 2021
We are now entering the third decade of the 21st Century, and, especially in the last years, the achievements made by scientists have been exceptional, leading to major advancements in the fast-growing field of Oncology. Frontiers has organized a series of Research Topics to highlight the latest advancements in research across the field of Oncology, with articles from the Associate Members of our accomplished Editorial Boards. This editorial initiative of particular relevance, led by Prof. David Eisenstat, Specialty Chief Editor of the Neuro-Oncology and Neurosurgical Oncology section, together with Prof. Erik Sulman, focused on new insights, novel developments, current challenges, latest di...
Media Events in Web 2.0 China
This book is among the first to use a "media events" framework to examine China's Internet activism and politics, and the first study of the transformation of China's media events through the parameter of online activism. The author locates the practices of major modes of online activism in China (shanzhai [culture jamming]; citizen journalism; and weiguan [mediated mobilisation]) into different types of Chinese media events (ritual celebration, natural disaster, political scandal). The contextualised analysis of online activism thus enables exploration of the spatial, temporal and relational dimensions of Chinese online activism with other social agents -- such as the Party-state, mainstrea...
