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Epigenetic Regulation of Autophagy in Inflammatory Diseases
Epigenetics refers to changes in the expression of heritable genes or cellular phenotypes caused by regulating DNA methylation, histone modification, chromatin remodeling, and noncoding RNA expression, without altering the DNA sequence. It plays a critical role in the regulation of many physiological and pathological processes, such as inflammation, immunity, and tumor. In particular, many epigenetic modifiers have been found to affect innate cell development, infection, and inflammatory responses by regulating gene-specific expression. Epigenetic abnormalities often result in changes in gene expression and its function, which in turn promote the process of inflammation and even tumorigenesi...
Advanced Interpretable Machine Learning Methods for Clinical NGS Big Data of Complex Hereditary Diseases, 2nd Edition
Publisher’s note: This is a 2nd edition due to an article retraction
Primary and Acquired Resistance in Lung Cancer
Lung cancer is one of the leading causes of cancer-related death worldwide with a prevalence of advanced stage in up to 70% of cases and a five-year survival reached in only 5-10% of cases. Targeted therapies and immunotherapy have greatly improved the management of patients with advanced non-small cell lung cancer (NSCLC), particularly adenocarcinoma, and current diagnostic algorithms are based on the molecular analysis of several biomarkers necessary to tailor therapy. In detail, patients harboring sensitive driver alterations within the oncogenes EGFR, BRAF, ALK, ROS1, RET and NTRK1/2/3 can be treated with approved kinase inhibitors (KIs). In addition, drugs against MET, KRAS G12C and other markers are providing interesting results across different clinical trials. Targeted therapies have greatly improved therapeutic options for NSCLC, but resistance inevitably occurs usually after one year of treatment and some patients, although harboring sensitive alterations, never respond to treatment.
Web Information Systems and Mining
The volume LNCS 7529 constitutes the refereed proceedings of the International Conference on Web Information Systems and Mining, WISM 2012, held in Chengdu, China, in October 2012. The 87 revised full papers presented were carefully reviewed and selected from 418 submissions. The papers are organized in topical sections on applications of Web information systems; applications of Web mining; e-government and e-commerce; information security; intelligent networked systems; management information systems; mobile computing; semantic Web and ontologies; Web information extraction; Web intelligence; Web interfaces and applications; and XML and semi-structured data.
Information Networking
This book constitutes the refereed proceedings of the International Conference on Information Networking, ICOIN 2005 held in Jeju Island, Korea in January/February 2005. The conference focused on convergence in broadband and mobile networking. The 96 revised full papers presented were carefully reviewed and selected from 427 submissions. The papers are organized in topical sections on wireless LAN, security, TCP and congestion control, wireless ad-hoc network routing, network measurement, routing, power control in wireless networks, quality of service, high speed networks, wireless ad-hoc networks, network design, peer-to-peer networks, and applications and services.
