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Time and Frequency: Theory and Fundamentals
The document is a tutorial Monograph describing various aspects of time and frequency (T/F). Included are chapters relating to elemental concepts of precise time and frequency; basic principles of quartz oscillators and atomic frequency standards; historical review, recent progress, and current status of atomic frequency standards; promising areas for developing future primary frequency standards; relevance of frequency standards to other areas of metrology including a unified standard concept; statistics of T/F data analysis coupled with the theory and construction of the NBS atomic time scale; an overview of T/F dissemination techniques; and the standards of T/F in the USA. The Monograph addresses both the specialist in the field as well as those desiring basic information about time and frequency. The authors trace the development and scope of T/F technology, its improvement over periods of decades, its status today, and its possible use, applications, and development in days to come.
Long Non-Coding RNAs
Long non-coding RNAs (lncRNAs), tentatively defined as ncRNAs of more than two hundred nucleotides in length, are characterized by the complexity and diversity of their sequences and mechanisms of action. Based on genome-wide studies, more than 3,300 of them exist, but to date only the limited number of functional lncRNAs have been identified and characterized. Nonetheless, lncRNAs have emerged as key molecules involved in the control of transcriptional and posttranscriptional gene regulatory pathways. They take part in the recruitment of chromatin modifying complexes and regulate splicing, localization, stability and translation of the target mRNAs. This book provides an overview of the rapidly advancing field of long ncRNAs, describing the epigenetic and non-epigenetic mechanisms by which they regulate various biological functions in model systems, from yeast to mammals. The role of ncRNAs in sex chromosome dosage compensation in flies and mammals is described, as well as their role in centromere and telomere biology. Long non-coding RNAs involved in environmental stress response and development are presented and their mechanisms of action discussed.
The Golden Rule
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