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Computational Modeling of Genetic and Biochemical Networks
How new modeling techniques can be used to explore functionally relevant molecular and cellular relationships.
Computational Modeling Of Gene Regulatory Networks - A Primer
This book serves as an introduction to the myriad computational approaches to gene regulatory modeling and analysis, and is written specifically with experimental biologists in mind. Mathematical jargon is avoided and explanations are given in intuitive terms. In cases where equations are unavoidable, they are derived from first principles or, at the very least, an intuitive description is provided. Extensive examples and a large number of model descriptions are provided for use in both classroom exercises as well as self-guided exploration and learning. As such, the book is ideal for self-learning and also as the basis of a semester-long course for undergraduate and graduate students in molecular biology, bioengineering, genome sciences, or systems biology./a
Computation in Cells and Tissues
The field of biologically inspired computation has coexisted with mainstream computing since the 1930s, and the pioneers in this area include Warren McCulloch, Walter Pitts, Robert Rosen, Otto Schmitt, Alan Turing, John von Neumann and Norbert Wiener. Ideas arising out of studies of biology have permeated algorithmics, automata theory, artificial intelligence, graphics, information systems and software design. Within this context, the biomolecular, cellular and tissue levels of biological organisation have had a considerable inspirational impact on the development of computational ideas. Such innovations include neural computing, systolic arrays, genetic and immune algorithms, cellular autom...
Automatic Algorithm Selection for Complex Simulation Problems
To select the most suitable simulation algorithm for a given task is often difficult. This is due to intricate interactions between model features, implementation details, and runtime environment, which may strongly affect the overall performance. An automated selection of simulation algorithms supports users in setting up simulation experiments without demanding expert knowledge on simulation. Roland Ewald analyzes and discusses existing approaches to solve the algorithm selection problem in the context of simulation. He introduces a framework for automatic simulation algorithm selection and describes its integration into the open-source modelling and simulation framework James II. Its selection mechanisms are able to cope with three situations: no prior knowledge is available, the impact of problem features on simulator performance is unknown, and a relationship between problem features and algorithm performance can be established empirically. The author concludes with an experimental evaluation of the developed methods.
VLSI for Neural Networks and Artificial Intelligence
Neural network and artificial intelligence algorithrns and computing have increased not only in complexity but also in the number of applications. This in turn has posed a tremendous need for a larger computational power that conventional scalar processors may not be able to deliver efficiently. These processors are oriented towards numeric and data manipulations. Due to the neurocomputing requirements (such as non-programming and learning) and the artificial intelligence requirements (such as symbolic manipulation and knowledge representation) a different set of constraints and demands are imposed on the computer architectures/organizations for these applications. Research and development o...
Gene Regulation and Metabolism
An overview of current computational approaches to metabolism and gene regulation.
Current Topics in Computational Molecular Biology
A survey of current topics in computational molecular biology. Computational molecular biology, or bioinformatics, draws on the disciplines of biology, mathematics, statistics, physics, chemistry, computer science, and engineering. It provides the computational support for functional genomics, which links the behavior of cells, organisms, and populations to the information encoded in the genomes, as well as for structural genomics. At the heart of all large-scale and high-throughput biotechnologies, it has a growing impact on health and medicine. This survey of computational molecular biology covers traditional topics such as protein structure modeling and sequence alignment, and more recent ones such as expression data analysis and comparative genomics. It combines algorithmic, statistical, database, and AI-based methods for studying biological problems. The book also contains an introductory chapter, as well as one on general statistical modeling and computational techniques in molecular biology. Each chapter presents a self-contained review of a specific subject. Not for sale in China, including Hong Kong.
Simulation Algorithms for Computational Systems Biology
This book explains the state-of-the-art algorithms used to simulate biological dynamics. Each technique is theoretically introduced and applied to a set of modeling cases. Starting from basic simulation algorithms, the book also introduces more advanced techniques that support delays, diffusion in space, or that are based on hybrid simulation strategies. This is a valuable self-contained resource for graduate students and practitioners in computer science, biology and bioinformatics. An appendix covers the mathematical background, and the authors include further reading sections in each chapter.
Mathematics of Neural Networks
This volume of research papers comprises the proceedings of the first International Conference on Mathematics of Neural Networks and Applications (MANNA), which was held at Lady Margaret Hall, Oxford from July 3rd to 7th, 1995 and attended by 116 people. The meeting was strongly supported and, in addition to a stimulating academic programme, it featured a delightful venue, excellent food and accommo dation, a full social programme and fine weather - all of which made for a very enjoyable week. This was the first meeting with this title and it was run under the auspices of the Universities of Huddersfield and Brighton, with sponsorship from the US Air Force (European Office of Aerospace Resea...
