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Understanding the Heart
“The most mind-blowing information on heart disease. . . . I consider this to be the best book I’ve ever read on cardiovascular health.”—Ben Greenfield, New York Times bestselling author Heart disease is the number-one killer in the world. Despite ever-advancing medical procedures and more and more powerful pharmaceutical drugs, the rate of heart disease continues to rise. According to Dr. Stephen Hussey, this is due in part to misunderstandings about how the heart really functions and how to keep it healthy. These misunderstandings result in improper medical approaches and off-target intervention therapies. As a type 1 diabetic, Dr. Hussey has always known that he was at two to four...
Novel Developments in Pharmaceutical and Biomedical Analysis
Recent Advances in Analytical Techniques is a series of updates in techniques used in chemical analysis. Each volume presents information about a selection of analytical techniques. Readers will find information about developments in analytical methods such as chromatography, electrochemistry, optical sensor arrays for pharmaceutical and biomedical analysis. Novel Developments in Pharmaceutical and Biomedical Analysis is the second volume of the series and covers the following topics: o Chromatographic assays of solid dosage forms and their drug dissolution studies o UHPLC method for the estimation of bioactive compounds o HILIC based LC/MS for metabolite analysis o In vitro methods for the evaluation of oxidative stress o Application of vibrational spectroscopy in studies of structural polymorphism of drugs o Electrochemical sensors based on conductive polymers and carbon nanotubes o Optical sensor arrays for pharmaceutical and biomedical analyses o Chemical applications of ionic liquids o New trends in enantioanalysis of pharmaceutical compounds
Environmental Toxicology and Ecosystem
This book covers varied aspects of environmental contaminants and their effect on the living organisms. It addresses the basics of ecotoxicity assessment, interaction of the abiotic or biotic factors with the novel chemical entities, and the fate of the natural organic matter upon interaction with new chemical entities. It further includes models for ecotoxicity studies and high-throughput approaches including OMICS. It provides an overview of the ecological risk assessment, regulatory toxicology guidelines, and possible roadmaps for protection of environmental health. Features: Discusses environmental toxicology facets and their effects on the ecosystem. Provides an introduction of environmental toxicology keeping in view the paradigm shift on entry of novel materials in the environment. Includes bioavailability, bioconcentration, and biomagnification of trophic transfer of pollutants. Covers high-throughput approaches for ecotoxicity assessment. Explores roadmaps for environmental protection and sustainable development. This book is geared toward graduate students and researchers in Environmental Sciences and Engineering, Toxicology, and Ecology.
How and why we get Alzheimer's disease
With regard to the sporadic form of Alzheimer's disease, a reduction to molecular-biological or genetic processes does not sufficiently contribute to the understanding of its development. Its pathogenesis only becomes clearer from an emergent perspective, a critical examination of the existing hypotheses on the development of the disease and the inclusion of fundamental scientific findings. Against an extremely complex background, the energetic factor stands out. The efficiency of some processes in cellular energy use and production points to principles of quantum information. In this context, potentially new diagnostic and therapeutic methods are discussed.
Modulators of Oxidative Stress
The book starts with the editors' preface summarizing the contributions of each of the following thirteen articles dealing with chemical and pharmacological aspects of the molecular modulators of the oxidative stress in regard to various therapeutic approaches in cardiovascular and neurodegenerative diseases, cancer, and diabetes. The seven articles present data from original research studies enlightening the roles and mechanisms of action of small molecular weight compounds (natural and synthetic; ascorbic acid/vitamin C, deferoxamine, N-acetylcysteine, MitoVitE, α-tocopherol, trolox, and ezetimibe) or proteins (SIRT3) in modulation of oxidative stress. In the six review papers, the authors present and discuss the possible therapeutic potential of novel approaches and compounds that are promising and deserve further investigation, in modulation of oxidative stress.
Eine andere Sicht auf die Entstehung der sporadischen Form der Alzheimerkrankheit
Bei der Alzheimerkrankheit soll einer Theorie nach als Plaques abgelagertes Amyloid krankheitsauslösend wirken, während dies einer anderen Hypothese zufolge durch nachlassende Energiebereitstellung durch Mitochondrien geschieht. Betroffene weisen kognitive Defizite, wie beispielsweise Gedächtnis- oder Orientierungsstörungen auf und erleben diesen Zustand unter anderem mit geänderter Affektivität und gestörtem Verhalten. Eine chronisch neurodegenerative Krankheit ließe sich durch prozessual bedingte Veränderungen auffassen, bei dem eine Abweichung von der Norm durch Pathomorphologie oder Dysfunktionalität erklärbar wird. Welche Substanz steckt aber dahinter? Um es vorweg zu nehmen:...
Pharmaceutical Toxicology
Toxicology studies are carried out on all drug substances to ensure safety. This book provides an overview of the methodology andrequirements of pre-clinical safety assessments of new medicines. with the focus on medicinal drugs - the most important safety issues of drugs are covered, including registration requirements of new drugs and pharmacovigilance. This is an introductory text for students at BSc, MSc and PhD levels,and will be an excellent companion to pharmacology textbooks, combining a broad treatment of the issues relevant for assessing the safety/efficacy balance of a new drug wit
ABSTRACT BOOK of I. INTERNATIONAL CONGRESS ON MEDICINAL AND AROMATIC PL ANTS
Dear Academicians, Readers and Educators, We are pleased to present the issue of the International Journal of Secondary Metabolite as a special issue entitled ‘I. International Congress on Medicinal and Aromatic Plants - “Natural And Healthy Life”’. This special issue contains some of scientific studies presented in the congress. Hosting the I. International Medical and Aromatic Plant Congress, held in Konya on 9-12 May 2017, by the coorperation T.R. Ministry of Forestry and Water Affairs, General Directorate of Forestry and Necmettin Erbakan University was a great honor for us. The total number of abstract submission for the congress was 1923. After the scientific evaluation, 85 abs...
Metals in Water
Metals in Water: Global Sources, Significance, and Treatment covers metal pollution in water, where they come from, their effects, and remediation processes. Sections overview heavy metals pollution, including their global health impacts and remediation measures. Geogenic and anthropogenic input of heavy metals in water are described, along with global case studies, step-by-step methods on remediation techniques, different detection sensors, and assessment practices of toxicity of heavy metals. The book focuses on recent research surrounding heavy metals' contamination in water resources and its impact across the globe. Chapters incorporate both theoretical and practical aspects and serve as...
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