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Venom and Toxin as Targeted Therapy
Targeted therapy has developed significantly in the last one and half decades, prescribing specific medications for treatment of particular diseases, such as cancer, diabetes, and heart disease. One of the most exciting recent developments in targeted therapies was the isolation of disease-specific molecules from natural resources, such as animal venoms and plant metabolites/toxins, for use as templates for new drug motif designs. In addition, the study of venom proteins/peptides and toxins naturally targeted mammalian receptors and demonstrated high specificity and selectivity towards defined ion channels of cell membranes. Research has also focsed intensely on receptors. The focus of this ...
ADAM, ADAMTS and Astacin Proteases: Challenges and Breakthroughs in the -Omics Era
Professor Hang Fai Kwok has two filed patents on ADAM17 antibody applications in cancer and cardiovascular disease. All other Topic Editors declare no competing interests with regards to the Research Topic.
Proteases and Cancer
This volume details bioinformatics analysis, biochemical assays, recombinant protein expression and purification, methods to investigate protease activity in cell-based, organoids and in vivo systems, proteomics, transcriptomics, machine learning and novel approaches to target dysregulated protease activity in cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cancer Immunotherapy: Methods and Protocols aims to provide the scientific community with a diverse and representative collection of state-of-the-art methods to investigate the protean functions of proteases in cancer biology.
Marine Biochemistry
This book provides the latest comprehensive methods for isolation and other novel techniques for marine product development. Furthermore, this book offers knowledge on the biological, medical, and industrial applications of marine-derived medicinal food substances. There has been a tremendous increase in the products derived from marine organisms for commercial application in industries every year. Functional foods of medicinal value are particularly in demand as new technology allows the stabilization of natural ingredients and their availability in pure forms to solve various human diseases. Marine flora and fauna have essential elements and trace minerals that nurture various hormones pro...
Custom, Land and Livelihood in Rural South China
Land was always at the centre of life in Hong Kong’s rural New Territories: it sustained livelihoods and lineages and, for some, was a route to power. Villagers managed their land according to customs that were often at odds with formal Chinese law. British rule, 1898—1997, added complications by assimilating traditional practices into a Western legal system. Custom, Land and Livelihood in Rural South China explores land ownership in the New Territories, analysing over a hundred surviving land deeds from the late Ch’ing Dynasty to recent times, which are transcribed in full and translated into English. Together with other sources collected by the author during 30 years of research, these deeds yield information on all aspects of traditional village life—from raising families and making a living to coping with intruders—and evoke a view of the world which, despite decades of urbanisation, still has resonance today.
Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases
Natural-based biomolecules continuously play an important role in novel drug discovery for the treatment of chronic diseases. The development of natural peptide/protein-based, toxin-based, and antibody-based drugs can significantly improve the biomedical efficiency of disease-specific therapy. The focus of this Special Issue of Biomolecules will be on the most recent advances related to novel peptides/proteins, antibodies, and toxins as forms of medicinal therapy. Recent advances in the discovery and development of these natural biomolecules for use in targeted therapy and immunotherapy against chronic diseases (e.g., cancer, diabetes, cardiovascular diseases, and rheumatoid arthritis) will be addressed. The discussion on using novel disease-specific proteins/peptides/toxins/antibodies along with currently available FDA-approved drugs as combinatorial treatments will also be encouraged in this context. Finally, an overview of some of the selected promising natural biomolecules that are potentially able to address the forthcoming challenges in this field will be included. Both research (in particular) and review articles proposing novelties or overviews, respectively, are welcome.
Constancy of Purpose
The Faculty of Medicine of the Universit of Hong Kong traces its origins back to the inauguration of the Hong Kong College of Medicine for Chinese on 1 October, 1987, of which Dr Sun Yat-sen was one of the the first and most illustrious graduates, and it accordingly celebrates its centenary in 1987. This volume relates the development of the Faculty from its beginnings and commemorates the establishment of one of the oldest and most reputable medical schools in South East Asia. It is hoped that it will be of special attraction and appeal not only to those connected with the Faculty but also a much wider audience interested in the development of modern medical education in this region.
