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Diagnostic, Prognostic and Predictive Factors of Response in the Era of Precision Oncology in Breast Cancer
In the last couple of decades, the study of the cancer genome and the progressive implementation of next-generation sequencing platforms have provided the Scientific and Oncology communities with a multitude of data, technologies, diagnostic, prognostic, and predictive tools that have been revolutionizing the way we can study, diagnose and treat cancer, including breast tumors. For example, genomic tests can now refine the prognosis of early-stage breast cancer patients beyond standard clinicopathological features and help guide escalated or de-escalated treatment choices. The identification of the molecular intrinsic subtypes might also be helpful in guiding treatment choices in advanced hormone receptor-positive disease. The identification of germline mutations in BRCA1 or BRCA2 has led to the development and introduction of PARP inhibitors for the treatment of advanced and early-stage breast cancer, along with personalized follow-up and prophylactic surgical procedures for patients with or without cancer, carrying such mutations.
Dermal Absorption and Decontamination
This book is a comprehensive volume dedicated to dermal absorption and decontamination. Given risks including chemical warfare and accidents with toxic industrial chemicals, studies involving dermal absorption and decontamination are of the utmost importance. Each chapter consists of a systematic review on an important dermal absorption and/or decontamination topic. Chapters address key issues such as the general acceptance of water/ soap and water as the gold standard of dermal decontamination despite the fact that it commonly provides incomplete decontamination and may even result in a “wash-in effect” (an increased penetration of contaminant). Decontamination with other substances (e....
Material Science And Environmental Engineering - The Proceedings Of 2016 International Workshop (Iwmsee2016)
The 2016 International Workshop on Material Science and Environmental Engineering (IWMSEE2016) was held in Wuhan, Hubei, China from January 22nd to January 24th, 2016. Out of the 214 submissions from various parts of the world, only 85 papers were chosen by the Technical Program Committee.IWMSEE2016 aims to bring together researchers, engineers and students from the areas of Material Science and Environmental Engineering to share and discuss the output of their research and the progress made, in the areas of Material Science and Engineering, Environmental Protection and Sustainable Development, Renewable Energy and Building Energy Saving, Environmental Science and Engineering, Modeling, Simulation and Control System and Safety Management.The conference program is extremely rich and profound and features high-impact presentations of selected papers and additional ground-breaking contributions. All the selected papers demonstrate elements of originality, significance and clarity for the purpose of this conference.
Wetlands and Water Resources: Ecological Solutions for the Environment
Wetlands are usually located in complex landscapes. Multiple ecosystem services delivered by wetlands to human well-being should be considered in broader contexts of wetland functions, water quality, water resource management and wetland conservation. Natural wetlands are 'kidneys' and 'sponges' of the earth that remove water pollutants and provide hydrological regulation functions vital to the environment. Where the functions of the wetlands are weakened, actions of rehabilitations are needed to revitalize those functions. While worldwide many natural wetlands have disappeared due to climate change and/or human activities, constructed wetlands, which may be seen as 'artificial kidneys/spong...
The South China Sea
Pinxian Wang and Qianyu Li The South China Sea (SCS) (Fig. 1. 1) offers a special attraction for Earth scientists world-wide because of its location and its well-preserved hemipelagic sediments. As the largest one of the marginal seas separating Asia from the Paci?c, the largest continent from the largest ocean, the SCS functions as a focal point in land-sea int- actions of the Earth system. Climatically, the SCS is located between the Western Paci?c Warm Pool, the centre of global heating at the sea level, and the Tibetan Plateau, the centre of heating at an altitude of 5,000m. Geomorphologically, the SCS lies to the east of the highest peak on earth, Zhumulangma or Everest in the Himalayas...
