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Antibodies have revolutionized medicine and biotechnology, and have become indispensable tools in therapy, diagnostics, analytics, and research. Therapeutic antibodies, for example, have come to dominate the ranks of blockbuster drugs, currently accounting for 10 out of the top 15 best-selling medicines. At the same time, a body of case law dealing specifically with the patentability of antibody-related inventions and the enforcement of antibody patents has emerged in major jurisdictions. The, at times, significant divergences between different jurisdictions have been compounded by recent decisions in the United States, most notably Amgen v. Sanofi, 872 F.3d 1367 (Fed. Cir. 2017), which have...
Since the Financial Crisis in 2008 Germany has performed economically far better than most of its neighbouring countries. What makes Germany so special that nobel prize winner Krugman called it a German miracle and is this sustainable? Is it its strong economic and political institutions, in particular trade unions, which by international comparison are a solid rock in turbulent waters, its vocational training which guarantees high skilled labour and low youth unemployment, its social partnership agreements which showed large flexibility of working time arrangements during the crisis and turned the rock into a bamboo flexibly bending once the rough wind of globalization was blowing? Or was i...
This is an introduction to the methods and applications of polymerase chain reaction (PCR) technology, a technology developed by Erlich's group at Cetus and Cetus, and is expected to be used in all biology laboratories worldwide within the next few years.
Including new developments and publications which have appeared since the publication of the first edition in 1995, this second edition: *gives a comprehensive introductory account of event history modeling techniques and their use in applied research in economics and the social sciences; *demonstrates that event history modeling is a major step forward in causal analysis. To do so the authors show that event history models employ the time-path of changes in states and relate changes in causal variables in the past to changes in discrete outcomes in the future; and *introduces the reader to the computer program Transition Data Analysis (TDA). This software estimates the sort of models most frequently used with longitudinal data, in particular, discrete-time and continuous-time event history data. Techniques of Event History Modeling can serve as a student textbook in the fields of statistics, economics, the social sciences, psychology, and the political sciences. It can also be used as a reference for scientists in all fields of research.
Marriage and social inequality are closely interrelated. Marriage is dependent on the structure of marriage markets, and marriage patterns have consequences for social inequality. This book demonstrates that in most modern societies the educa tional system has become an increasingly important marriage market, particularly for those who are highly qualified. Educational expansion in general and the rising educational participation of women in particular unintentionally have increased the rate of "assortative meeting" and assortative mating across birth cohorts. Rising educational homogamy means that social inequality is further enhanced through marriage because better (and worse) educated sin...