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The Molecular Biology of Cancer
The Molecular Biology of Cancer discusses the state of progress in the molecular biology of cancer. The book describes the effects of anticancer agents on nucleolar ultrastructure; the role of chromosomes in the causation and progression of cancer and leukemia; the replication, modification, and repair of DNA. The text also describes the metabolism and utilization of messenger RNA and other high molecular weight RNA and low molecular weight nuclear RNA; the characteristics, structures, and functions of nuclear proteins; and the process of protein synthesis. Nucleotides are reviewed with regard to its biosynthesis, inhibition of synthesis, and development of resistance to inhibitors. The book further tackles the biochemical mechanisms of chemical carcinogenesis; the oncogenic viruses; and the molecular correlation concept. The text also demonstrates phenotypic variability as a manifestation of translational control; and plasmacytomas. Molecular biologists, virologists, pathologists, cell biologists, oncologists, pharmacologists, and students taking related courses will find the book useful.
The Cell Nucleus V1
The Cell Nucleus, Volume I reports the basic concepts of cell nucleus, including nuclear structure, the interaction between the nucleus and cytoplasm, and the chromatin. This volume first describes the nucleus’ morphological structures and relates these structures to its functions. It then discusses nuclear organization in plant cells; morphology and biochemistry of the slime mold nucleus; and structure, function, and properties of nuclear envelope. In addition, it addresses the molecular movements between nucleus and cytoplasm against a concentration gradient, presents experiments with animal cell heterokaryons, and explains the genome in specialized cells. It also explores the organization of the chromatin fiber; the human chromosome structure before and after banding; and the ultrastructure and function of heterochromatin and euchromatin.
The Cell Nucleus V2
The Cell Nucleus, Volume II covers mainly the chromosomes, including its pathology. It also reviews the information onthe isolated mitotic apparatus highlighting on its chemistryand relevant morphology. This volume particularly discusses the mammalian chromosomes, the staining techniques, the kinetics of DNA replication in chromosomes, and the difference of meiotic chromosomes from mitotic chromosomes. It also presents studies on isolated mammalian metaphase chromosomes; chromosomes of birds and plants; as well as the polytene chromosomes of the two-winged insects, the Diptera. Furthermore, this volume describes the giant chromosomes. Lastly, the autosomal disorders, the abnormalities of sex development, and types of virus-induced chromosome alterations are explained to elucidate the pathology of chromosome.
The Cell Nucleus V3
The Cell Nucleus, Volume III focuses mainly on nucleic acids, nuclear proteins, and special aspects of nuclear functions. This volume particularly discusses the organization of bacterial and viral DNA, as well as the nuclear DNA of eukaryotic organisms. It also describes nuclear DNA polymerases, precursors of messenger RNA, ribonucleoproteins, and nuclear high- and low-molecular-weight RNAs. Furthermore, this volume looks into the two broad classes of nuclear proteins: histones and nonhistone proteins. It also presents advances made in the knowledge of mammalian DNA-dependent RNA polymerase, cytochemical detection of nuclear enzymes, and nuclear protein synthesis. Moreover, it elucidates the effects of female steroid hormones on target cell nuclei, describes the nucleus during avian erythropoiesis, and reports the general properties of intranuclear viruses.
Histones and Other Nuclear Proteins
Histones and Other Nuclear Proteins provides an introduction to the status of research and knowledge of histones and nuclear proteins. This book discusses the classification of the nuclear proteins, the role of proteins in control of the genome, repressor substances, and history of the nuclear proteins. Other topics include the primary structure of protamines, amino acid composition of histones, and direct isolation of nucleoproteins. The relationship of histones to chromosome structure, effects of histones on DNA synthesis, and sequential analysis of amino acids in the N-proline histone fraction is also deliberated. This text likewise covers the labeling of histones in vivo, physical and chemical properties of the acidic nuclear proteins, and enzymes involved in synthesis of nucleic acids. This publication is valuable to chemists and students aiming to acquire knowledge of histones and other nuclear proteins.
Chromatin
The Cell Nucleus: Chromatin, Part A is a collection of papers that deals with the fundamental research involving cellular responses to environmental stimuli and stress. One paper describes the ultra-structural organization of chromosomes and certain eukaryotic chromatin fractions as seen by a scanning electron microscope. The researcher investigating chromatin three-dimension ultra-structure is presented with two choices to address the technical limitations of SEM at different levels, namely, (1) electron microscope modality and (2) specimen preparation procedures. Another paper explains the extensive postmortem changes in properties occurring in nuclear preparations during purification and ...
The Nucleolus
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