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NMR-based Metabolomics
This book describes the state of the art in the application of NMR spectroscopy to metabolomics and will be a key title for researchers and practitioners.
Unmasking metabolic dependencies for anti-cancer treatment in cancer
Over the last decade, our understanding of metabolism in the context of cancer has evolved greatly. It is now evident that altered cellular metabolism is an integral effector of tumorigenesis that is intricately intertwined with cell signaling as well as genetic and epigenetic regulation of diverse tumor programs. Recognizing the dysregulation of cellular metabolism as an important aspect of tumor function has offered new potential direction to seek clinical benefit by providing targets for the development of novel therapeutics. To-date, several small molecule inhibitors that target tumor or immune cell metabolism are being explored in active clinical trials as either preventive, stand-alone, or adjuvant therapies for various malignancies. Thus, identifying critical metabolic vulnerabilities in pre-neoplastic cells, cancer cells, and immune cells has direct and timely relevance for developing additional treatment and preventative strategies against cancer.
Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods
The nutraceutical and functional food field is rapidly growing in diverse sectors, including academic, commercial and government. This has brought a corresponding shift in research focus and in public awareness. Understanding the relevance of the scientific principles in determining the safety and effectiveness of functional foods and nutraceuticals is increasingly important. It is becoming increasingly evident that genomic research technologies will be used in the coming years and there is a need to provide resources that will facilitate this growth. This book incorporates the most recent advances in the three major sectors of the field within one volume. Genomics, proteomics, and metobolomics represent three major scientific research areas that contribute to nutraceutical and functional food research for studies of effectiveness and safety.
Biomarkers
This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers. The book has chapters on topics including HIV, Cancer, Parkinson’s, vascular injury, environmental exposure. A following section discusses the technologies (diagnostics and assays) to detect biomarkers and authors have emphasized the preclinical and clinical manifestation of the injury/disease process.
Integrative Approaches in Environmental Health and Exposome Research
Research on the relationship between health and the environment in a postgenomic context is increasingly aimed at understanding the various exposures as a whole, simultaneously taking into account data pertaining to the biology of organisms and the physical and social environment. Exposome research is a paradigmatic case of this new trend in environmental health studies. This book takes a multidisciplinary approach focusing on the conceptual, epistemological, and sociological reflections in the latest research on environmental and social determinants of health and disease. It offers a combination of theoretical and practical approaches and the authors are scholars from a multidisciplinary background (epidemiology, geography, philosophy of medicine and biology, sociology). Crucially, the book balances the benefit and cost of the integration of biological and social factors when modelling aetiology of disease.
Emerging Bioinformatic Tools in Toxicogenomics
Toxicogenomics was established as a merger of toxicology with genomics approaches and methodologies more than 15 years ago, and considered of major value for studying toxic mechanisms-of-action in greater depth and for classification of toxic agents for predicting adverse human health risks. While the original focus was on technological validation of in particular microarray-based whole genome expression analysis (transcriptomics), mainly through cross-comparing different platforms for data generation (MAQC-I), it was soon appreciated that actually the wide variety of data analysis approaches represents the major source of inter-study variation. This led to early attempts towards harmonizing...
Kale: The Everyday Superfood
Super foods for a super you Kale is everywhere—but what if you easily bore of salads and smoothies? Kale the Everyday Superfoodgoes beyond the basics with: Super-tasty recipes including Kale Eggs Florentine, Sausage & Kale Skillet, and Kale Mac & Cheese Tips on selecting the best bunch and growing your own kale Easy labels for any diet: vegan, paleo, gluten-free, or total omnivore Kale myths—busted! A handy breakdown of kale’s nutritional qualities Burst: 150 satisfying kale recipes + 1 kale-free surprise treat!
Mediterranean Diet
This text is an especially timely new text as the number of studies focusing on the impact of the Mediterranean diet on disease prevention increases every year. The fundamental question addressed in this text is how food components and behavior of the Mediterranean diet reduce the risk of chronic diseases. In-depth chapters provide an overview of preclinical and clinical studies on Mediterranean dietary patterns, food components and lifestyle and their impact on health and disease. Large-scale “omic” approaches are highlighted to educate the reader about the molecular mechanisms through which specific components of the Mediterranean diet improves health and the opportunities and challenges for translating into practice the food recommendations of the Mediterranean pyramid. The volume concludes with information about the nutritional adequacy of Mediterranean foods and provides selected recipes. Mediterranean Diet: Impact on Health and Disease will be of great interest to students, clinicians, and scientists engaged in promoting health through nutrition and physical activity.
Ethnobotany and Ethnopharmacology of Medicinal and Aromatic Plants
Medicinal and aromatic plants are beneficial to human health. Plant-derived molecules possess biological activities that can be used to prevent many infectious diseases and metabolic disorders. Ethnobotany and Ethnopharmacology of Medicinal and Aromatic Plants summarizes techniques and methods used to study the biological activities of plant-derived extracts and compounds to study ethnobotanical and ethnopharmacological features of medicinal and aromatic plants. This book: Includes computational approaches to study the pharmacological properties of biomolecules in medicinal and aromatic plants. Details methods in ethnopharmacology including chromatographical and analytical techniques. Demons...
