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Transient Receptor Potential Channels
Transient Receptor Potential Channels offers a unique blend of thoughtfully selected topics ranging from the structural biology of this fascinating group of ion channels to their emerging roles in human diseases. This single book covers TRP channels of yeasts, flies, fishes frogs and humans. And from the biophysics of primary thermo-sensory events in cells to the thermosensation at whole organism level, from physiology of pain to the development of pain-killers, from psychiatric illnesses to cancers, from skin cells to sperms, from taste buds to testes, from established facts to heated debates, this book contains something for every TRP enthusiasts, beginner and expert alike. It includes crucial background information, critical analysis of cutting edge research, and ideas and thoughts for numerous testable hypotheses. It also shows directions for future research in this highly dynamic field. It is a book readers will be just as eager to give to others as keep for themselves.
The Devil's Garden
Fresh look at D-Day, one of World War II's pivotal battles, in time for its 70th anniversary in June 2014 Explains why the U.S. Army suffered enormous casualties on Omaha Beach Focuses on Erwin Rommel, the Desert Fox, who oversaw German defenses in Normandy Covers little-known aspects such as the German patrols tasked with shooting down the pigeons the French Resistance used to send messages to the Allies Relies on original research, including recently discovered German artillery maps Zaloga's well-supported conclusions are sure to spark debate
Manual of Antisense Methodology
In the past few years, antisense methodology has moved from in vitro studies to in vivo studies and first human trials. While the basic concept of antisense technology is simple, the methodological problems associated with its use are numerous and complex. Antisense- based methods have proven to be a field of research where careful attention to experimental protocols and appropriate controls is necessary. The Manual of Antisense Methodology emphasizes the application of antisense oligonucleotides, and is a guide for the identification of antisense and non-antisense effects in different experimental settings. The work is organized into three sections: antisense application in vitro, antisense application in vivo (animal models) and finally, clinical antisense studies. Where at all possible, the methods are described in sufficient detail to allow reproduction of a given experiment. The Manual of Antisense Methodology will be of interest to researchers in immunology, cancer research, pharmacology and internal medicine; and physicians conducting clinical studies in these fields.
Difference Gel Electrophoresis
The second edition of this volume provides a comprehensive update of this key method on gel-based proteomics. Chapters present an introduction into the development of methods on principles of differential protein labeling and two-dimensional gel electrophoresis, techniques on optimized proteomic workflows using advanced mass spectrometry for protein identification, and the application of those methods in basic biological research, pathobiology and applied biomarker discovery. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Difference Gel Electrophoresis: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.
Federal Register
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Composition and Function of the Extracellular Matrix in the Human Body
The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book overviews the role of the ECM in different tissues and organs of the human body.
Der Vereinsbote
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Stützpunkt WN 62 - Normandie 1942-1944
Lesen Sie jetzt alles über die Hintergründe zum größten deutschen Stützpunkt am Omaha Beach: WN 62, bekannt aus Hein Severlohs Biografie! Normandie, 6. Juni 1944: D-Day! Die Alliierten wagen den Sturm auf die "Festung Europa". Die Landung in der Normandie gilt als eine der größten Militäroperationen der Menschheitsgeschichte. Untrennbar mit ihr verknüpft sind menschliche Tragödien, militärische Fehlschläge, schier unglaubliche Einzelschicksale und abenteuerliche Geheimnisse ... Der renommierte D-Day-Experte und Historiker Helmut Konrad von Keusgen, bekannt aus einschlägigen Print-, Radio- und TV-Dokumentationen zum D-Day, ist weltweit geschätzt für seine einzigartige Aufarbeit...
