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Advances in Stem Cell Aging
Adult stem cells are present in most postnatal tissues of mammals. Tissues with high rates of cell turnover depend on the functional capacity of stem cells for lifelong maintenance of tissue homeostasis. Adult stem cells are also required for the regeneration of tissues in response to injury as in, for example, the regeneration of skeletal muscle. In addition to its function in tissue homeostasis and regeneration, adult stem cells can represent the cell type of origin of various types of cancers including leukemia and colorectal cancer. Stem cells are the most long-lived cells in the proliferative compartment of mammalian tissues. Therefore, stem cells have an increased risk of acquiring mutations that could ultimately lead to the transformation of tissue stem cells.This publication presents the current knowledge in the field of stem cell aging, which was discussed at the Else Kröner-Fresenius Symposium on Advances in Stem Cell Aging in 2011. It will be of special interest to scientists working on stem cell research, aging, regeneration, and cancer as well as physicians and scientists specializing in geriatric medicine, internal medicine, and surgery.
A Companion to Nazi Germany
A Deep Exploration of the Rise, Reign, and Legacy of the Third Reich For its brief existence, National Socialist Germany was one of the most destructive regimes in the history of humankind. Since that time, scholarly debate about its causes has volleyed continuously between the effects of political and military decisions, pathological development, or modernity gone awry. Was terror the defining force of rule, or was popular consent critical to sustaining the movement? Were the German people sympathetic to Nazi ideology, or were they radicalized by social manipulation and powerful propaganda? Was the “Final Solution” the motivation for the Third Reich’s rise to power, or simply the outc...
The Life We Claim
Using the Apostles’ Creed as the “primary text” this book explores what we believe as Christians and how those beliefs are relevant today. The author’s goal is to help pastors educate and transform members of their congregations. He examines the Creed phrase by phrase in brief sections suitable for congregational study or for emailing to the congregation. For each phrase in the Creed, a "deeper reflection" provides material for preaching a 13-sermon series or for further congregatonal study. A detailed appendix includes recommendations of hymns and songs related to each phrase in the Creed; the suggestions are keyed to several hymnals and songbooks.
Model organisms in inflammation and cancer
A link between inflammation and cancer was initially made by Rudolf Virchow back in the 19th century. Nowadays many cancers are considered dependent on inflammatory responses to microbial and damaged-self stimuli and both arms of immunity, innate and adaptive, are playing a role in promoting cancer. Moreover, besides environmental factors, opportunistic pathogens contribute to inflammation and cancer. Nevertheless, microbial influence on chronic disease is sometimes difficult to discern, especially in the context of polymicrobial communities, such as those found in the digestive tract. In this light, model organisms provide important insights into immune and growth signals that promote cancer, and suggest therapies that will selectively target potentially harmful microbes or modulate host responses. A number of review and opinion articles in this series address novel aspects and paradigms of the interactions between the microbiota and the host in relation to inflammation and cancer.
Heads of State and Government
Macmillan published the first edition of this text in 1985. It is a detailed reference to world leaders, monarchs, presidents and their equivalents, executive leaders plus other positions with authority vested in them; heads of ruling communist parties, military junta heads and some leaders with no formal post, but who wield supreme authority. This text is a reference to leaders, past and present, of the countries of the world. The second edition updates the first and includes the far reaching political changes which have taken place in Eastern Europe and the emergence of new states. The scope of the book has been broadened to include more international organisations, more regional government leaders, more governments in exile and colonial governors of the twentieth century.
Active and Real-Time Database Systems (ARTDB-95)
The areas of active and real-time databases have seen a tremendous growth of interest in the past few years, particularly with regard to their support of time-critical and embedded applications. ARTDB-95 provided, therefore, an important forum for researchers from both communities to discuss research results, and also to chart new directions for the future. As well as the 11 submitted papers presented at the workshop, this volume also contains 4 invited papers on the following topics: the impact of active databases on commercial practice; the optimization of active database transactions; the need for better language, compiler and tool support for real-time databases; and the origin of time constraints associated with data, events and actions. Together the papers give a comprehensive overview of current research, and will provide invaluable reading for academic and industrial researchers and students at both undergraduate and postgraduate level.
