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Nearly three thousand papers and patents are dedicated to the actual or potential uses of cyclodextrins in pharmacy and pharmaceutical formulations. This is the first book written for pharmacists and pharmaceutical technologists which not only critically summarizes the enormous amount of literature available, but which can be used as a handbook when looking for solutions to practical problems. The fundamentals -- chemistry of cyclodextrins and their derivatives -- their physical and chemical properties are condensed to the most relevant items in Chapters 1 and 2. Chapter 3 deals with the adsorption, metabolism and toxicological properties of cyclodextrins. Chapter 4 explains the formulation,...
Illegal psychoactive substances and illicit prescription drugs are currently used on a daily basis all over the world. Affecting public health and social welfare, illicit drug use is linked to disease, disability, and social problems. Faced with an increase in usage, national and global policymakers are turning to addiction science for guidance on how to create evidence-based drug policy. Drug Policy and the Public Good is an objective analytical basis on which to build global drug policies. It presents the accumulated scientific knowledge on drug use in relation to policy development on a national and international level. By also revealing new epidemiological data on the global dimensions o...
Drug addiction is a chronically relapsing mental illness involving severe motivational disturbances and loss of behavioral control leading to personal dev- tation. The disorder af?icts millions of people, often co-occurring with other mental illnesses with enormous social and economic costs to society. Several decades of research have established that drugs of abuse hijack the brain’s natural reward substrates, and that chronic drug use causes aberrant alterations in these rewa- processing systems. Such aberrations may be demonstrated at the cellular, neu- transmitter, and regional levels of information processing using either animal models or neuroimaging in humans following chronic drug ...
A leading expert on drug use illuminates the factors that permit some people to use such highly addictive and dangerous substances as alcohol, marijuana, psychedelics, and opiates in a controlled fashion. This cogently written work should be of interest to members of the medical community, particularly those who have contact with substance abusers, psychiatrists, sociologists, policymakers, administrators, and interested laypersons...Well worth reading. -- JAMA
Addiction in its various forms represents an enormous challenge to society. Worldwide, it has been estimated that alcohol, tobacco and illicit drugs were responsible of more than 10 million deaths (Anderson et al, 2018), with a higher impact in developed countries where substance use disorders have been identified as responsible for life expectancy reversals (Rehm et al, 2016). Societal and medical responses to the problem are far from optimal, but the appearance of new technologies offers room for improvement, and lots of new initiatives have been launched and developed. In this Special Issue, we will describe and discuss how these new tools are helping to improve the assessment and treatment of substance use disorders. We will cover a wide variety of novelties that are being applied to addiction; e-health, APPs, digital phenotyping, ecological momentary assessment and interventions, wearable technology, computer-assisted tests, transcraneal magnetic stimulation, and virtual reality are just some examples of developments in a field that promises to create a real revolution in the assessment and treatment of addictions.
Japanese Frames of Mind addresses two main questions in light of a collection of research conducted by both Japanese and American researchers at Harvard University: What challenge does Japanese psychology offer to Western psychology? Will the presumed universals of human nature discovered by Western psychology be reduced to a set of 'local psychology' among many in a world of unpredicted variations? The chapters provide a wealth of new data and perspectives related to aspects of Japanese child development, moral reasoning and narratives, schooling and family socialization, and adolescent experiences. By placing the Japanese evidence within the context of Western psychological theory and research, the book calls for a systematic reexamination of Western psychology as one psychology among many other ethnopsychologies. Written in mostly non-technical language, this book will appeal to developmental and cultural psychologists, anthropologists interested in psychological anthropology, educators, and anyone interested in Japanese and Asian studies.
Fungal diseases have been with us from antiquity; interest in the chemo therapy of fungal disease has exploded in the past decade. To plan and pro duce a book on the topic of antifungal chemotherapy has come as a personal challenge - and something of an eye-opener - towards the end of my re search career. A landmark publication which still merits reading is Antifungal Chemotherapy (John Wiley & Sons, Chichester, UK), edited by David Speller, which appeared in 1980. However, the fact that ketoconazole, the first of the modern, orally active, wide-spectrum antifungals, attracted no more than two sentences in it indicates just how far we have come in the 1980s. A steady stream of original paper...
This volume will be aimed at medicinal chemistry and emerging drug discovery scientists.
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Both pain and addiction are tremendous public health problems. Practitioners of every stripe say that they learned precious little about pain or addiction in their training and readily admit that instruction on the interface of pain and addiction is nonexistent. The recent problem of prescription drug abuse has only served to highlight the fact that these two worlds need unificationthose who treat pain must be informed about the risks of controlled substances and those who treat addiction need to better and more fully understand their benefits. Nowhere is the pooled knowledge of pain management and addiction medicine brought together to allow for a greater appreciation of the risks of addict...