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Sleep-Related Breathing Disorders
Systematically assessing the relative strengths and weaknesses of various animal model systems, this reference presents an overview of the known pathophysiology of sleep-related breathing disorders. It focuses exclusively on animal-based experimental approaches to improve current diagnostic and therapeutic practices in the management of these disorders. Providing a fundamental understanding of sleep-related breathing disorders, the book introduces sleep disorders and applies modern neuroscience to regulation of breathing during sleep. The authors have collected nearly all known studies, summarized the date, and provided easy to understand diagrams, charts, and figures.
Suppressing the Mind
Anesthetics produce a reversible state of unconsciousness accompanied by ante- grade amnesia. This remarkable phenomenon brings great relief to surgical patients and wonder to clinicians and scientists. To date, we do not fully understand the mechanisms by which anesthetics ablate conscious sensation and memory. We are, however, making progress. This book presents original results as well as overviews of the current state of knowledge of the problem. It is authored by investigators who know the ?eld well; their research at a number of levels has contributed substantially to our c- rent understanding of anesthetic modulation of memory and consciousness. Most of the contributors were presenter...
Biology of Sleep, An Issue of Sleep Medicine Clinics
This issue of Sleep Medicine Clinics, Guest Edited by Teofilo Lee-Chiong MD, will focus on Biology of Sleep, with article topics including: Neurology of Sleep; Normal Sleep and Circadian Rhythms: Neurobiologic Mechanisms Underlying Sleep and Wakefulness; Physiology of Sleep Disordered Breathing; Evaluation of the Patient Who Has Sleep Complaints: A Case-Based Method Using the Sleep Process Matrix; Sleep States,Memory Processing, and Dreams; Neurobiologic Mechanisms in Chronic Insomnia; Sleep Behavior and Sleep Regulation from Infancy through Adolescence: Normative Aspects; Biological Timekeeping; Neurologic Basis of Sleep Breathing Disorders; Genetics of Sleep Timing, Duration, and Homeostasis in Humans; Sleep in Normal Aging; Modulation of Endocrine Function by Sleep-Wake Homeostasis and Circadian Rhythmicity; Cardiac Activity and Sympathovagal Balance During Sleep; Sleep and Cytokines; Neuropharmacology of Sleep and Wakefulness; Staging Sleep; Respiratory Physiology During Sleep; and Cyclic Alternating Pattern (CAP), Sleep Disordered Breathing, and Automatic Analysis.
Sedation and Analgesia for Diagnostic and Therapeutic Procedures
Physicians, nurses, and safety experts comprehensively review sedation and analgesia to provide a completely new reference guide to safe sedation practices consistent with existing guidelines. Starting with an integrated review of the basic physiology and neurobiology of the sedated state, the authors proceed through clinical guidelines and practices, and conclude with an examination of quality-outcome measures and processes. They also review current mandates for safe sedation practices and address the key clinical issues of pharmacology, monitoring, and recovery. Special tables and figures throughout the book summarize protocols, regulatory requirements, recommended dosages, monitoring requirements, and quality assurance tools.
Neuroscientific Foundations of Anesthesiology
Although the perioperative care of patients by anesthesiologists draws on diverse clinical skills, the principles of anesthesiology and pain management are rooted in the neurosciences. The Neuroscientific Foundations of Anesthesiology thoroughly examines the anesthetic modulation of the central, peripheral, and autonomic nervous systems and will help redefine anesthesiology as a fundamentally neuroscientific field. The book is organized by sections, with each focusing on a different part of the nervous system. State-of-the-art chapters written by thought-leaders in anesthesiology and neuroscience provide a novel and invaluable resource.
The Orexin/Hypocretin System
Impairment of orexin/hypocretin signaling causes narcolepsy-cataplexy in animals and humans. Most human narcolepsy-cataplexy cases are associated with orexin/hypocretin ligand deficiency, which can be detected clinically using cerebrospinal orexin/hypocretin measures and may lead to future treatments with orexin/hypocretin replacement therapy. In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians review these exciting developments to set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness by the orexin/hypocretin system, and the role of the orexin/hypocretin system in many other p...
Neurochemistry of Sleep and Wakefulness
Pharmacological approaches to our understanding of sleep have been at the forefront of sleep research for many years. Traditional techniques have included the use of pharmacological agonists and antagonists, as well as transmitter-specific lesions. These have been enhanced by the introduction of molecular genetics and the use of transgenes and targeted gene deletion. Neurochemistry of Sleep and Wakefulness is an exceptional, single source of information on the role of the major mammalian neurotransmitter systems involved in the regulation of sleep and waking. With contributions from internationally recognized experts, this book clearly describes how researchers have made use of the myriad techniques in their armamentarium to characterize the role of a given neurotransmitter in the regulation of sleep and waking. Suitable for experimental and clinical pharmacologists, the book will have wider appeal to sleep researchers, psychiatrists and any professional interested in the interdisciplinary areas of neurobiology and pharmacology.
The Master Illusionist
Federico Sanchez’s interest in the brain began--primarily related to artificial intelligence and computers--while studying mechanical engineering at Tufts University in the early 70’s. For the next three decades he studied the human brain sporadically as an ongoing hobby. But, after the death of his younger son by suicide in 2002, using the latest research on the brain, he committed to explain not only how suicide is possible but how most other mental disorders come about. He synthesized his findings in The Master Illusionist, Principles of Neuropsychology a groundbreaking study on the inner workings of the human brain from an engineering perspective. This is a new paradigm-setting study...
Rapid Eye Movement Sleep
Spanning over half a century of investigation into Rapid Eye Movement (REM) sleep, this volume provides comprehensive coverage of a broad range of topics in REM sleep biology. World renowned researchers and experts are brought together to discuss past and current research and to set the foundation for future developments. Key topics are covered in six sections from fundamental topics (historical context and general biology) to cutting-edge research on neuronal regulation, neuroanatomy and neurochemistry, functional significance and disturbance in the REM sleep generating mechanism. A reference source for all aspects of REM sleep research, it also incorporates chapters on neural modelling, findings from non-human species and interactions between brain regions. This is an invaluable resource, essential reading for all involved in sleep research and clinical practice.
