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Respiratory Physiology
Present-day respiratory physiology stems largely from the explosion of ideas which took place during and after World War II. A number of the major players are still active, but the opportunity to prepare a personal history of this branch of medicine will soon be lost. In a sense then, this book offers an exceptional, even unique, opportunity. We are offered a first-hand chronicle of the advancements made in respiratory physiology in the course of this century by one of the principal figures in the field. The volume covers every aspect of the evolution of this important area of knowledge: morphology, gas exchange and blood flow, mechanics, control of ventillation, and comparative physiology. Some of the chapters are personal accounts of the development of respiratory physiology as observed by the author. It is hoped that what is lost in objectivity by this approach is more than made up by the captivating insights provided by the author into the process of scientific research and discovery.
Arterial Chemoreceptors in Physiology and Pathophysiology
Every three years, the International Society for Arterial Chemoreception (ISAC) arranges a Meeting to bring together all of the major International research groups investigating the general topic of oxygen sensing in health and disease, with a prime focus upon systemic level hypoxia and carotid body function. This volume summarises the proceedings of the XIXth meeting of the Society, held in Leeds, UK during the summer of 2014. As such this volume represents a unique collection of state of the art reviews and original, brief research articles covering all aspects of oxygen sensing, ranging from the molecular mechanisms of chemotransduction in oxygen sensing cells such as the carotid body type I cells, to the adverse, reflex cardiovascular outcomes arising from carotid body dysfunction as seen, for example, in heart failure or obstructive sleep apnoea. This volume will be of tremendous interest to basic scientists with an interest in the cellular and molecular biology of oxygen sensing and integrative, whole organism physiologists as well as physicians studying or treating the clinical cardiovascular consequences of carotid body dysfunction.
Frontiers in Arterial Chemoreception
Proceedings of the XIIIth International Symposium, held in Santiago, Chile, March 25-29, 1996
Chemoreception
Since 1959, the International Society of Arterial Chemoreception (ISAC) has organized in a variety of countries fifteen scientific meetings devoted to the mechanisms of peripheral arterial chemoreception and chemoreceptor reflexes. After the meeting held in Philadelphia with Sukhamay Lahiri as president, ISAC membership elected Lyon (CNRS, University Claude Bernard, France) as the site of the xv" ISAC Symposium. The Symposium was effectively held in Lyon from the 18th to the 22nd of November 2002 and Jean-Marc Pequignot was its president. The organizers were Jean-Marc Pequignot and Yvette Dalmaz Lyon (CNRS, University Claude Bernard, France) and the Scientific Committee was formed by John Ca...
The Electrophysiology of Neuroendocrine Cells
The Electrophysiology of Neuroendocrine Cells explores the role of electrical activity in neuroendocrine cells in stimulus-secretion coupling, sensory mechanisms, and intercellular communication. This comprehensive and concise handbook includes introductory material on the ontogenesis and classification of the neuroendocrine system and describes general electrical properties, voltage-gated ion channels, and the pharmacology of ion channels. By focusing on functional aspects, The Electrophysiology of Neuroendocrine Cells provides research scientists, physicians, and students with a basic understanding of neuroendocrine cells and their similarity to neurones, as well as their relationship to thyroid- or steroid-hormone secreting endocrine cells. The multidisciplinary nature of this book provides readers with a broad perspective on the electrical properties of neuroendocrine cells, and the combination of general information and specialized information makes the book accessible to beginning and advanced readers alike.
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Wandering in the Gardens of the Mind
Peter Mitchell, winner of the 1978 Nobel Prize for chemistry for his chemiosmotic theory, was a highly original scientist who revolutionized our understanding of cellular metabolism and bioenergetics. This is the only full biography of Mitchell, and it should be of considerable interest to biophysicists, biochemists, and physicians and researchers focusing on metabolism, as well as historians of medicine and biology.
Signalling Pathways in Acute Oxygen Sensing
Oxygen sensing is a key physiological function of many tissues, but the identity of the sensor, the signalling pathways linking the sensor to the effector, and the endpoint effector mechanisms are all subjects of controversy. This book evaluates the various mediators that have been proposed, including the mitochondria, NAD(P)H oxidases, cytochrome p450 enzymes, and direct effects on enzymes and ion channels. There has been a resurgence of interest in the role of mitochondria, based partly on the ability of mitochondrial inhibitors to mimic hypoxia, but there is little consensus concerning mechanisms. Some favour the view that the primary signalling event is a reduction in cell redox state an...
Testosterone Dreams
Testosterone has inspired dreams—of restored youth, recharged sexual appetites, faster running, quicker thinking, bigger muscles—since it was first synthesized in 1935. This provocative book investigates the complex, bizarre, and sometimes outrageous history of synthetic testosterone and other male hormone therapies. Exploring many little-known social arenas—both inside and outside the medical world—in which these substances are becoming increasingly available and accepted, Testosterone Dreams examines the implications and dangers of their use in professional sports, in the workplace, in our sex lives, and beyond. Testosterone Dreams tells the story of testosterone's growing and some...
