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Intratumor Diversity and Clonal Evolution in Cancer
This specialized volume of Advances in Cancer Research is dedicated to the complex and largely unexplored field of intratumor diversity, with respect to differences in both genotype and phenotype among cell populations within tumors. Unique subject matter: there are relatively few previous publications covering this complex topic, even though it has been a matter of much speculation ever since cancers were first studied under the microscope more than a century ago. This volume is an attempt to update the reader on novel findings as well as giving a historical perspective to the field. It thereby offers an excellent starting point for young scientists entering this field of research Contributors: many of the contributors are renowned cancer researchers with long-term experience. To bring in new ideas to the field, these experienced authors have been blended with young bright minds who might provide novel starting points for solving old problems Technical aspects: some chapters will be focused on specific techniques to address intratumor diversity and will therefore be helpful for colleagues wanting to broaden their technical expertise
FISH
Fluorescence in situ hybridization (known as FISH) is a well-established technique in cytogenetics that has become an important tool in general molecular and cellular biology.
Endoplasmic Reticulum Stress Response and Transcriptional Reprogramming
Endoplasmic reticulum (ER) is an intracellular organelle responsible for protein folding and assembly, lipid and sterol biosynthesis, and calcium storage. A number of biochemical, physiological, or pathological stimuli can interrupt protein folding process, causing accumulation of unfolded or misfolded proteins in the ER lumen, a condition called “ER stress”. To cope with accumulation of unfolded or misfolded proteins, the ER has evolved a group of signaling pathways termed “Unfolded Protein Response (UPR)” or “ER stress response” to align cellular physiology. To maintain ER homeostasis, transcriptional regulation mediated through multiple UPR branches is orchestrated to increase...
Cancer Research
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Relaxation Revolution
"In Relaxation Revolution, Dr. Herbert Benson and William Proctor present the latest scientific endings, revealing that we have the ability to self-heal diseases, prevent life-threatening conditions, and supplement established drug and surgical procedures with mind body techniques. In a special "treatment" section, Benson and Proctor describe how these mind body techniques can be applied - and are being applied - to treat a wide variety of conditions..."--Publisher.
Fluorescence In Situ Hybridization (FISH) - Application Guide
This book is a unique source of information on the present state of the exciting field of molecular cytogenetics and how it can be applied in research and diagnostics. The basic techniques of fluorescence in situ hybridization and primed in situ hybridization (PRINS) are outlined, the multiple approaches and probe sets that are now available for these techniques are described, and applications of them are presented in 36 chapters by authors from ten different countries around the world. The book not only provides the reader with basic and background knowledge on the topic, but also gives detailed protocols that show how molecular cytogenetics is currently performed by specialists in this fie...
Meiosis and Gametogenesis
In spite of the fact that the process of meiosis is fundamental to inheritance, surprisingly little is understood about how it actually occurs. There has recently been a flurry of research activity in this area and this volume summarizes the advances coming from this work. All authors are recognized and respected research scientists at the forefront of research in meiosis. Of particular interest is the emphasis in this volume on meiosis in the context of gametogenesis in higher eukaryotic organisms, backed up by chapters on meiotic mechanisms in other model organisms. The focus is on modern molecular and cytological techniques and how these have elucidated fundamental mechanisms of meiosis. ...
Current Topics in Developmental Biology
This Series provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The Series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.
The Truth in Small Doses
A decade ago Leaf, a cancer survivor himself, began to investigate why we had made such limited progress fighting this terrifying disease. The result is a gripping narrative that reveals why the public's immense investment in research has been badly misspent, why scientists seldom collaborate and share their data, why new drugs are so expensive yet routinely fail, and why our best hope for progress-- brilliant young scientists-- are now abandoning the search for a cure.
